Crespo-Barrios works in regenerative medicine and virology. His area of expertise involves the multidisciplinary fields of AI, proteomics/interactomics, cellish (the language of cells in the cellular crosstalk), applied to immunological and cardiovascular bioengineering. This includes the design of antiviral agents on one hand, and angioregenerative (in all its therapeutic forms, such as angiogenesis, arteriogenesis, etc.) and immunoregenerative approaches on the other.