Want to live forever? Join the club!
Join the growing number of people who are committed to living forever. Now that healthcare has merged with IT the exponential growth in medical technology means immortality may be closer than you think. From drug research and diagnostics to exoskeletons and nanobots – rapid advances are increasing our life expectancy every day.
Radical life extension is a growing industry – and more and more people are putting (a lot!) of money where their mouths are:
- 5 billionaires who want to live forever – Fortune Magazine
- Understanding Calico: Larry Page, Google Ventures, and the quest for immortality – The Verge
- Oracle founder Larry Ellison has proclaimed his wish to live forever and donated more than $430 million to anti-aging research. – Washington Post
Why Some People Go Into Type 2 Diabetes Remission – Health Line – 7-Aug-18
Patients with type 2 diabetes put on a yearlong calorie-restrictive diet.
Almost half of the participants achieved nondiabetic blood sugars.
Remission not because of “reversing insulin resistance.”
Weight loss resulted in improved function of their pancreatic beta cells.
Diabetes Strong cautions against rapid weight loss and severe calorie restriction.
Research based on UK Diabetes Remission Clinical Trial (DiRECT).
Cellular aging halted by hydrogen sulfide gas – Medical News Today – 7-Aug-2018
University of Exeter targeted splicing factors within the mitochondria.
Used samples of endothelial cells that line the inside of blood vessels.
Team designed novel chemicals that targeted either SRSF2 or HNRNPD.
Compounds delivered a minute dose of hydrogen sulfide gas to mitochondria.
Gas fires up the splicing factors, giving mitochondria a boost.
Senescent cells in the sample dropped by an impressive 50 percent.
UK among worst for life expectancy rises – BBC News – 7-Aug-2018
Increases in life expectancy in the UK have stalled.
Slowdown is one of the biggest among world’s leading economies.
Still increasing by a month a year between 2011-16.
Government austerity policies may have played a part.
Babies born in the UK in 2016 can expect to live 79/83 (male/female).
Even low levels of air pollution can damage heart – BBC News – 3-Aug-2018
People living by loud, busy roads have larger hearts on average.
Even though exposure was to pollution levels below UK guidelines.
Exposure to higher pollution levels linked to larger ventricles .
One microgram of PM2.5 caused the heart to enlarge by about 1%.
Every 10 extra micrograms per m3 of NO2 had the same effect.
Queen Mary University studied 4,000 people in the UK.
Hospital sepsis deaths ‘jump by a third’ – BBC News – 3-Aug-2018
Sepsis deaths in England’s hospitals increase by more than a third in two years.
Sepsis was the cause of death in 15,722 deaths.
Staff shortages and overcrowding on wards are partly to blame.
Statistics may be partly ware to increase in awareness and detection of sepsis.
Sepsis is a complication of an infection and can lead to multiple organ failure.
Symptoms include slurred speech, extreme shivering and severe breathlessness.
COMMENT: keep an eye on your loved ones if they’re in hospital
Protein Patterns of Ill Health – The Scientist – 2-Aug-2018
Certain sets of proteins are associated with common conditions of aging.
Blood samples taken from over five thousand of elderly Icelanders.
Measured 4,137 known and predicted serum proteins within the samples.
Found 27 distinct networks, or modules, of proteins across the cohort.
Many of the networks were associated with specific complex diseases.
Also revealed patterns of expression associated with overall mortality.
More Belly Fat Means More Cognitive Impairment – Trinity College Dublin – 1-Aug-2018
Waist-to-hip ratio associated with reduced cognitive function in older adults
Due to increased secretion of inflammatory markers by belly fat.
TUDA study comprised over 5,000 Irish individuals >60 years of age.
20-somethings not getting enough nutrients – NHS – 31-Jul-2018
Survey of 3,238 adults aged 20 to 59.
Participants logged what they consumed over 4 consecutive days.
20-29 year old group had the highest rates of potential deficiencies.
Potassium (24.7%), zinc (8.6%) and calcium (9.4%).
Can help keep the body healthy and prevent chronic diseases.
Should be able to get all micronutrients needed from a balanced diet.
Life Extension Is Not Selfish – Leaf Science – 31-Jul-2018
People often accused of being selfish for wanting to extend their lives.
Life extension is about eliminating suffering caused by diseases of old age.
Being a life extensionist implies that you must care about global issues.
Far-future issues, beyond a normal lifespan, become your problem too.
Nuclear bunker uses 42 buried school buses – BBC News – 31-Jul-2018
Ark Two Shelter is one of Canada’s largest nuclear shelters.
Designed to protect people from fallout for 3 weeks.
Contains over 50 rooms built into 42 buried school buses.
– side arm drop point
– decontamination area
– 5,000 gallon stainless steel water tank
Bruce Beach is ready for a nuclear apocalypse.
And optimistic that society will ultimately prevail.
Can We Terraform Mars to Make It Earth-Like? – Space – 30-Jul-2018
Mars is a hopeful “Planet B” if Earth fails.
Terraforming is the process of changing the conditions on a planet.
It would make Mars habitable for Earth life without life-support systems.
New paper says terraforming Mars not possible with existing technologies.
Would need to raise temperatures and thicken the atmosphere.
not enough CO2 on Mars to make the planet Earth-like.
Pandemic could kill 900 million people – Metro – 30-Jul-2018
John Hopkins University simulated the spread of a new illness.
Clade X is a theoretical new type of parainfluenza.
Pathogen wasn’t markedly more dangerous than SARS.
American politicians ran an exercise as if a virus was released.
Estimates that 10% of the world’s population would perish.
Parkinson’s Disease Treatment Enters Human Trials – Newsweek – 30-Jul-2018
Kyoto University will begin testing the new treatment on humans.
Will inject induced Pluripotent Stem cells into the patients’ brains.
iPS cells can develop into neurons that produce dopamine.
In animal trials. movement of monkeys with Parkinson’s disease improved.
Stem cell reservoir found in teeth – CGTN Live – 26-Jul-2018
Rene Garcia tested the pulp in his son’s baby tooth.
Found to be a rich source of stem cells.
Could be frozen for fifty years for later use.
Dr. Rosalvira Nuñez is encouraging people to donate their teeth.
Conjoined twins hint at brain interface – ABC News – 25-Jul-2018
Conjoined twins have separate brains but can communicate thoughts.
They see able to see or feel each other’s sensory input.
FMRI showed connection via a single passage to the thalamus.
The two million neurons can convey emotion, awareness and sensation.
“We can have telepathic communication … of all our cognitive awareness.”
Mini Brains Grown in a Dish – Labiotech – 25-Jul-2018
New lab grown mini brains able to model cancers.
Brain cancers are cellular complex and difficult to study.
Organoids contain diverse cell types.
Researchers can observe how cancers grow and develop.
Can also be used for preclinical drug testing.
How the rich plan to survive the apocalypse – The Guardian – 24-Jul-2018
Or “The Event” is this group called whatever takes everything down.
How would they pay the guards once money was worthless?
What would stop the guards from choosing their own leader?
The future of technology is just about escape.
A bubble on Mars would be a lifeboat for the elite.
COMMENT: I’ve asked myself some similar questions for a long term plan of a Live Forever Lodge
Higher temperatures result in more suicides – The Guardian – 23-Jul-2018
Economic recessions known to increase rates of self-harm.
Impact of climate change on suicides may be as significant.
Temperature rise of 1C results in 0.7% more suicides in the US.
Even larger rate rise (2.1%) in Mexico.
Rise seen irrespective of wealth and the usual climate of the area.
Suicide is a top 10–15 cause of death globally.
Other research links 2,000 suicides a year in India to climate change.
Caution Regarding CRISPR Gene Therapies – Singularity Hub – 23-Jul-2018
CRISPR can cause more unintended damage than thought.
Enzyme cuts a cell’s DNA and relies on the cell to reconnect.
Can cause large deletions or rearrangements of DNA around the target site.
Fears this kind of damage to DNA could lead to cancer.
Has gone unnoticed as looking for small mutations.
Changes in the DNA have been seriously underestimated
Activity increases healthspan in older adults – News Medical – 23-Jul-2018
1,500 Australians aged over 50 followed for 10 years.
People with the highest activity levels still in optimal physical and mental shape.
Half the chance of stroke, heart disease, cancer and diabetes.
Greatest reduction in those exceeding 5000 metabolic equivalent minutes each week.
Almost 10x the World Health Organization recommendation.
Can Aging Genes Be Altered by a Face Cream? – Vogue – 21-Jul-2018
Environmental factors can affect the epigenome.
A gene for skin elasticity may power down by age 40.
Various companies attacking different pathways.
Biologique Recherche uses a peptide-powered formula.
Sisley’s serum acts on the enzyme linked to elastin.
Bader users stem-cell technology originally used for burns.
Avoiding controversy by making cosmetic, not medical, claims.
8 Types of Robotic Surgery Being Used Today – Nanalyze – 20-Jul-2018
Mazor Robotics spine surgery
Accuray radiosurgery for tumours.
Intuitive Surgical’s da Vinci is removing gallbladders.
Auris Health robotic endoscope
PROCEPT BioRobotics removes enlarged prostate tissue.
Medrobotics for ear, nose and throat surgeries.
THINK Surgical for orthopaedic surgery.
Restoration Robotics for hair loss.
Telomere loop structure more important than length – Medical Xpress – 20-Jul-2018
People born with abnormally short telomeres suffer a variety of conditions.
New research identifies why telomeres change from healthy to unhealthy with age.
Telomeres normally form a loop structure, where the chromosome end is hidden.
When loop unfolds, the chromosome end is exposed and perceived as broken DNA.
It is not telomere length that matters, but telomere structure.
New super-resolution microscopy allows loops to be seen.
Fish oil supplements for a healthy heart ‘nonsense’ – BBC News – 18-Jul-2018
Cochrane researchers looked at trials in over 100,000 people.
Little proof that taking omega-3 prevented heart disease.
Does not benefit heart health or reduce risk of stroke or death from any cause.
Prof Tim Chico advises spending money on vegetables instead.
Eating oily fish still recommended as part of a healthy diet.
Robot revolutionises study of new molecules – Independent – 18-Jul-2018
University of Glasgow chemists have trained an artificially-intelligent robot.
AI robot automatically explores a very large number of chemical reactions.
Machine-learning algorithms can uncover new reactions and molecules.
Could lower costs for discovering new drug molecules.
Already discovered a range of previously unknown new molecules and reactions.
AI researchers sign pledge against killer robots – The Guardian – 18-Jul-2018
Scientists declare they will not develop robots that can attack people without human oversight.
Co-founder of Google DeepMind and CEO of SpaceX among the 2,400 signatories.
Highlights dangers of handing over life and death decisions to AI-enhanced machines.
Future of Life Institute organised pledge calls for laws and regulations.
“A human must always be in the loop” – Toby Walsh, professor of AI.
$30 million venture philanthropy fund to tackle Alzheimer’s – Business Insider – 17-Jul-2018
Investors include Bill Gates, Leonard Lauder and the Charles and Helen Schwab Foundation.
$30 million Diagnostics Accelerator to investigate ideas for diagnosing Alzheimer’s earlier.
Current Alzheimer’s diagnoses are expensive, complex and invasive procedures.
Gates hopes to find a simple blood test or eye exam.
How to predict the side effects of millions of drug combinations – Kurzweil AI – 17-Jul-2018
Stanford University has developed a deep-learning system called Decagon.
Uses a model of how proteins in our bodies interact with each other and different drugs.
Could help doctors make better decisions about which drugs to prescribe.
May also help researchers find better combinations of drugs to treat complex diseases.
Millions of people take up to five or more medications a day.
Leukaemia blood test breakthrough – Independent – 9-Jul-2018
Acute myeloid leukaemia (AML) can become life-threatening without warning.
DNA mutations are measurable up to five years before it emerges.
Bone marrow mutations cause the over production of neutrophils and monocytes.
Researchers used blood samples from 800 patients in EpiC.
Similar markers may exist for other types of leukaemia.
Cleara Biotech Joins the Race to Develop Senolytic Therapies – Leaf Science – 9-Jul-2018
Last year its drug candidate was effective while leaving healthy cells unharmed.
Removes senescent cells using interaction between FOXO4 and p53.
Apollo Ventures had been looking for a marker specific to senescent cells.
Cleara will spend the next year optimizing the peptide.
Aim to bring a safe, effective senolytic therapy into human clinical trials.
What would you do with an extra thumb? – The Verge – 6-Jul-2018
Dani Clode 3D-printed a Third Thumb.
The thumb connects to a bracelet containing wires & servos.
Wearer controls it using pressure sensors in shoes.
Wants to reframe prosthetics as extensions of the body.
Augmentation enables new ways of manipulating objects.
COMMENT: opposable thumbs gave humans a big advantage – why not increase it?
The Supplements Ray Kurzweil takes – Ray and Terry – 1-Jul-2018
Ray has opened up recently about his supplement regime.
His top 3 are Phosphatidylcholine, Resveratrol and Ubiquinol.
Other supplements include anti-inflammatories and blood thinners.
Also pills for brain health, digestion and detoxification.
What are skin serums? – Harvard Health – 12-Jun-2018
Serums are light, easily absorbed oil- or water-based liquids.
Skin serums are not moisturisers and can be applied before them.
Dr. Waldman recommends serums that contain vitamins C & E, and ferulic acid.
Intensive dose of ingredients can address common skin complaints.
Can prevent brown spots, reverse UV damage, and stimulate new collagen.
Tea polyphenols and resveratrol target wrinkles.
Dry skin benefits from vitamin E, niacinamide, and glycolic acid.
Price doesn’t seem to make much difference – check the ingredients.