Want to live forever? Join the club!
Join the growing number of people who are committed to living forever. Now that healthcare has merged with IT the exponential growth in medical technology means immortality may be closer than you think. From drug research and diagnostics to exoskeletons and nanobots – rapid advances are increasing our life expectancy every day.
Radical life extension is a growing industry – and more and more people are putting (a lot!) of money where their mouths are:
- 5 billionaires who want to live forever – Fortune Magazine
- Understanding Calico: Larry Page, Google Ventures, and the quest for immortality – The Verge
- Oracle founder Larry Ellison has proclaimed his wish to live forever and donated more than $430 million to anti-aging research. – Washington Post
Age At First Period Could Determine Life Expectancy – Marie Claire – 17-Sep-2017
The Women’s Health Initiative collected data from 16,000 post-menopausal women.
And researchers from University of California, San Diego found that women who got their first period at age 12 or older indicated a likelihood of longer life; menopause after the age of 50 was also an indicator of good health.
Human Transplant Organs Should Be As Common As Cell Phones – Newsweek – 16-Sep-2017
Joseph Vacanti one of the authors of “The Vacanti Mouse” – a mouse with a human ear on its back reveals details about that story two decades later.
He believes in order to create human body parts they just need another million dollars in funding so they could do the final large animal experiments that could lead to a human trial.
“..over a billion people on planet earth need new organs… So the notion that we can help all those people with just what we currently do is not correct.,” said Vacanti.
Still Vulnerable 100 Years after Lethal 1918 Flu Pandemic – Scientific American – 15-Sep-2017
The 1918 influenza pandemic: the most devastating infectious disease in history took 50 million to 100 million lifes worldwide. Despite the progress of modern medicine we do not have such vaccines, which would be effective against a 1918-like virus. The three recent influenza pandemics in 1957, 1968 and 2009 remind us that new pandemics are inevitable, and that current seasonal vaccines are unlikely to prevent or significantly control them.
Type 2 diabetes plan targets those at high risk – BBC News – 15-Sep-2017
People with the highest risk of developing type 2 diabetes are being prioritised for places on NHS lifestyle change programmes. The programmes help people to change their diet and do more exercise.
According to NHS England there are currently 5 mln people in England at high risk of developing type 2 diabetes.
Poor diet is a factor in one in five deaths globally – The Guardian – 14-Sep-2017
According to ongoing study of Global Burden of Disease eating a diet that is low in whole grains, fruit, nuts and seeds and fish oils and high in salt raises the risk of an early death.
It finds that people are living longer but spending more years in ill health. And the wrong diet is the second highest risk factor for early death after smoking.
Today, 72% of deaths are from non-communicable diseases for which obesity and diet are among the risk factors, with ischaemic heart disease as the leading cause worldwide of early deaths.
New Drug Slows Down Heart Disease Progression – LEAF science – 14-Sep-2017
PCSK9 inhibitors are an effective therapy for lowering LDL cholesterol.
Combination of evolocumab and statins significantly reduced risk of cardiovascular events.
Evolocumab is a human monoclonal antibody that inhibits proprotein convertase subtilisin-kexin 9.
PCSK9 protein reduces the liver’s ability to remove LDL cholesterol from the blood.
Patients with under 10 mg/dL LDL cholesterol had 40 % lower risk of CV events.
New Bio-Ink Could 3D Print Artificial Organs – Futurism – 13-Sep-2017
Bio-ink is made of cold-soluble gelatin and remains stable at room temperature.
A big drawback of conventional hydrogel is its thermal instability.
Forms healthy tissue scaffolds for new cells to grow on.
Inexpensive and performed better than pig or fish skin.
Tracking of medical nanobots comes a step closer – The Engineer – 13-Jun-2017
One problem with nanobots (aka capsule endoscopes) is tracking their location once ingested.
ATOMS (addressable transmitters operated as magnetic spins) technique uses magnetic fields.
Integrated sensors and resonators mimic the magnetic resonance properties of atoms.
The chip has a surface area of 1.4 mm²
In future could incorporate sensors into small pills that detect pH, temperature, pressure and blood sugar concentrations.
It is quite possible to slow aging and extend life span – Bio Spectrum – 13-Sep-2017
Interesting interview with Prof Brian Kennedy appointed to lead ongoing efforts at the National University of Singapore.
“Reversing the aging process is still an open question that requires more research.”
Patients’ illnesses could soon be diagnosed by AI – The Guardian – 12-Sep-2017
Computers could start diagnosing patients’ illnesses within the next few years as artificial intelligence increasingly ousts doctors from their traditional roles.
NHS belives that machines may soon be able to read X-rays and analyse samples of diseased tissue, such as lumps that can indicate the presence of breast cancer.
Anti-Aging Pilot Studies Announced – LEAF science – 12-Sep-2017
Non-profit Betterhumans announced its intention to begin small-scale trials of senolytic therapies.
The aim is to remove toxic senescent cells from the body in a bid to address age-related diseases.
The organization found out that combination of dasatinib and quercetin, has enjoyed success in mice in a number of studies. It improved mouse health and, in some cases, even increased lifespan.
The pilot studies aim to find out whether it will have the same positive results to humans.
NHS hospitals missing sepsis treatment target – BBC News – 11-Sep-2017
Sepsis is a rare but serious complication of an infection. Without prompt treatment, it can lead to multiple organ failure and death.
According to NHS data 44,000 deaths happening every year in the UK, and 14,000 are preventable deaths.
37% of patients that need antibiotics for sepsis are not getting them within an hour.
14 hospital trusts are only screening one in every two people with signs of sepsis.
One in four NHS hospital trusts is failing to give antibiotics to half their patients with sepsis within the recommended time.
Australian researchers stop melanoma spreading – Medical Xpress – 11-Sep-2017
The Sydney-based Melanoma Institute Australia conducted 2 drug trials of new treatments and have proved it successful in preventing melanoma spreading in stage three patients whose tumours had been surgically removed.
The researchers conducted two 12-month trials, one immunotherapy-based and the other with targeted therapies.
Institute claims that their aim is to make melanoma a chronic rather than a terminal illness.
UK falls behind rest of Europe for life expectancy growth – The Guardian – 10-Sep-2017
Sir Michael Marmot the author of a report on health inequality claims that UK risked becoming the “sick man and woman of Europe”.
His analysis found that the UK is falling further behind, with growth in female life expectancy at birth the worst in Europe and male growth the second worst.
In Britain, the female life expectancy at birth is 83, below the EU average, while for men it is slightly above the average at 79.
Ilia Stambler Publishes New Text on Longevity Promotion – IEET – 10-Sep-2017
Book considers the multidisciplinary aspects of longevity promotion
Including advocacy, historical, philosophical and scientific perspectives.
Available on Amazon.
Should we embrace an enhanced future? – BBC – 9-Sep-2017
Do we all have the right to enhance our bodies as technology and pharmaceuticals will allow, or is that immoral?
As the probably over-used term has it, would that be “playing God”? And who gets to decide?
Public perception of new technology though is often cold to begin with.
As technology moves inexorably forward, we are being faced with new questions about how enhanced we want ourselves and everyone else to be.
In answering those questions, perhaps we need to recognise how enhanced we already are.
Biologists slow ageing process in fruit flies – IB Times – 7-Sep-2017
As people age, their mitochondria often become damaged – damaging the cells where any build-up occurs.
Mitochondria in middle-aged fruit flies start to enlarge from their small, round shape.
Cells not able to clear the damaged mitochondria.
UCLA researchers used Drp1 protein to break them up into smaller pieces.
In flies and mice, levels of Drp1 decline with age.
Also need Atg1 gene for the anti-ageing technique to work.
Flies to become more energetic and lived longer than usual (females 20%, males 12%).
Statins cut heart deaths in men with high cholesterol – NHS– 7-Sep-2017
Original randomised trial studied men who had high cholesterol.
Analysed the effects of taking statins or a placebo for five years.
Follow up study looked at heart disease statistics 20 years later.
Men who’d originally taken pravastatin were 26% less likely to have CHD.
Direct correlation between telomere length and heart failure found – Medical Xpress– 7-Sep-2017
Study used human heart tissue samples from organ donors and heart transplants patients.
Measured telomere lengths in the samples from patients with and without heart disease.
In healthy people, age did not play a role in telomere length.
Patients with heart failure had shorter telomeres regardless of their age.
Smartphone-connected ECG detects undiagnosed Atrial Fibrillation – Mobi Health News – 6-Sep-2017
Over 35 million people around the world unknowingly suffer from Atrial Fibrillation.
AFib is the leading predictor of stroke and heart failure.
Multiple studies show Kardia Mobile smartphone-connected ECG successful in detecting AFib.
In 10,000 participants aged 50+, 30% of participants found to have AFib were previously undiagnosed.
The robot that eliminates cancer cells using X-rays – DAWN – 5-Sep-2017
CyberKnife uses X-ray cameras to monitor the position of the tumour and moves with the patient’s breathing.
Has 360 degrees movement and can administer a larger dose of radiation more precisely.
Therefore fewer sessions are necessary.
Radiosurgery lasts 30-45 minutes and does not require anaesthesia.
Currently only 6 machines in the UK.
One in 10 men aged 50 ‘have the heart of a 60-year-old’ – NHS – 4-Sep-2017
Since 2015 Public Health England (PHE) are encouraging people to take a simple three-minute online Heart Age Test.
It includes questions about factors known to have an effect on cardiovascular disease risk.
PHE has analysed 1.2 million test results so far.
The main finding is that 1 in 10 men aged 50 who’ve taken the test were found to have a heart age of at least 60, and around half of people didn’t know their blood pressure.
Want to live longer? Find your ikigai – The Guardian – 3-Sep-2017
In Japan, retiring and not keeping your mind and body busy is seen as being bad for your health since it disconnects your soul from your ikigai (a reason for being).
Finding your ikigai is felt to be crucial to longevity and a life full of meaning.
Japanese keep doing what they love, what they are good at, and what the world needs even after they have left the office.
The idea is to keep mind and body active in order to fill yourself with purpose and ikigai on a daily basis.
This is one of the key reasons why Japan have the longest life expectancy in the world.
Computer knows how much pain you are in – New Scientist – 1-Sep-2017
A new algorithm can rate how much pain you are in just by looking at your face.
By examining tiny facial expressions and calibrating the system to each person, it provides a level of objectivity in an area where that’s normally hard to come by.
According to its creator Dianbo Liu the main challenge is measurment of pain levels as people express pain differently, so a doctor’s estimate of a patient’s pain can often differ from a self-reported pain score.
This systen might be useful in determining real pain from faked one.
KUKA’s New Medical Robot Enters Market – Engineering – 31-Aug-2017
KUKA’s LBR iiwa industrial robot, is designed for delicate assembly work.
The LBR Med is the first robotic component approved for integration into a medical product.
After certification, it can serve as a base for many medical devices. It is ideal for bone surgery.
KUKA is shipping the first orders for this robot in September 2017.
Nucleolus is a life expectancy predictor – Phys – 31-Aug-2017
The nucleolus is a major structure in a cell’s nucleus responsilbe for ribosome biogenesis.
Max Planck Institute for Biology of Ageing has discovered a link between its size and life expectancy.
Biomarker found in study of long-lived roundworm Caenorhabditis elegans mutants.
Mutants showed smaller nucleoli than their shorter-lived relatives.
Size link was independent of the pathway that led to their longevity.
Molecules within the nucleolus could causally impact life expectancy.
Effect also seen in human muscle biopsies.
How stars can nudge comets to strike Earth – The Guardian – 31-Aug-2017
A collision with a giant comet would be cataclysmic.
The odds of another such catastrophe have remained uncertain.
Astronomers have performed a risk assessment on the Oort cloud.
19 to 24 stars will come close enough to deflect comets in the next million years.
Not all dislodged comets would hit Earth.
Nanomachines constructed to destroy diseased cells (VIDEO) – RICE UNIVERSITY – 30-Aug-17
Motor is a paddle-like chain of atoms that spins when activated by a light source.
Spin between at 2-3 million times per second to overcome molecules and outpace Brownian motion.
The nanometer wide motors could locate specific cells of interest.
Takes at least a minute for a motor to tunnel through a membrane.
Highly unlikely that a cell could develop a resistance to molecular mechanical action.
AI-powered application to assess visual aging biomarkers in lab animals – LEAF – 29-Aug-2017
Lifespan.io is launching a crowdfunding campaign to support MouseAGE.
Software will assess visual biomarkers of aging in laboratory animals.
Project should increase the pace of research on aging.
While also reducing animal suffering in experiments.
FDA Cracks Down on Stem Cell Clinics – NY Times – 28-Aug-2017
The F.D.A. reported actions against two large stem cell clinics and a biotech company calling them “unscrupulous actors” in regenerative medicine.
This clinics used to extract stem cells from bone marrow, blood or fat and develop into many different types of cells in order to repair or replace tissue damaged by disease, injury or aging.
But so far, the F.D.A. has approved only a few stem-cell products.
The F.D.A. commissioner Dr. Scott Gottlieb announced that there is no proof that these methods are actually work.
As a result of stem cell treatment in one of these clinics one woman went blind and two others suffered severe, permanent eye damage.