Want to live forever? Join the club!
Join the growing number of people who are committed to living forever. Now that healthcare has merged with IT the exponential growth in medical technology means immortality may be closer than you think. From drug research and diagnostics to exoskeletons and nanobots – rapid advances are increasing our life expectancy every day.
Radical life extension is a growing industry – and more and more people are putting (a lot!) of money where their mouths are:
- 5 billionaires who want to live forever – Fortune Magazine
- Understanding Calico: Larry Page, Google Ventures, and the quest for immortality – The Verge
- Oracle founder Larry Ellison has proclaimed his wish to live forever and donated more than $430 million to anti-aging research. – Washington Post
Prepping for the apocalypse in New Zealand – The Guardian – 15-Feb-2018
If you’re interested in the end of the world, you’re interested in New Zealand.
What they’re after is space, and clean water.
Peter Thiel purchased a 477-acre former sheep station in the South Island.
Seen as a place of shelter from the coming flood.
The Sovereign Individual presents a bleak vista of a post-democratic future.
Ultra-processed foods ‘linked to cancer’ – BBC News – 15-Feb-2018
10% more ultra-processed in diet linked 12% more cancers detected.
Ultra-processed includes cakes, chicken nuggets and mass-produced bread.
The more of such foods people ate, the greater their risk of cancer.
On average, 18% of people’s diet was ultra-processed.
French study of 105,000 people using food surveys on two days.
Peter Diamandis launches new $250 million stem cells company – Tech Crunch – 15-Feb-2018
Celularity is a spinout from Celgene, a global biopharmaceutical company.
Hopes to use stem cells from placenta to regenerate tissue and organs.
Several clinical trials conducted – next step is FDA approval.
Approximately four million human placentas are disposed of per year in U.S. hospitals.
“Our ultimate mission is to make 100 years old the new 60” – Peter Diamandis.
Rich v poor life expectancy gap widening in the UK – Verdict – 15-Feb-2018
Boys born in prosperous neighbourhoods will live 8.4 years longer than those from a poor area.
Gap has been widening since the turn of the millennium
Not enough is being done to educate poorer people on the benefits of a healthier lifestyle.
Longevity Science Panel looked at ONS data 33,000 residential areas.
Summary of 800 Page State of Longevity Research Report – Singularity Hub -14-Feb-2018
Report produced by Biogerontology Research Foundation, Deep Knowledge Life Science, Aging Analytics Agency, and Longevity.International.
Healthcare systems aren’t ready for rapidly aging global population.
Two main streams of intervention with already promising results:
– understand the root causes of aging and stop them before damage accumulates
– rejuvenation biotechnology, i.e. repair and maintenance
Identified several technologies rapidly gaining steam:
– artificial intelligence in drug discovery, identifying longevity genes and personalized medicine
– senolytics, over 10 prospective candidates are already in the pipeline
– gene therapy can directly target the root of any pathology
Four additional volumes expected in 2018.
Synthetic nanofactory cell produces drugs in vivo – Silicon Republic – 14-Feb-2018
Synthetic cell produces anti-cancer proteins within tumour tissue.
Nanofactory cell HAS capacities similar and superior to natural cells.
Researchers integrated molecular machines within lipid-based particle.
Therapeutic proteins dictated by an integrated synthetic DNA template.
Successfully killed cancer cells in mice.
Antibiotics fail in fifth of post-op infections – The Telegraph – 13-Feb-2018
One in 10 patients in high-income countries develop an infection while recovering.
And of those, 17 per cent were found to be antibiotic resistant.
Levels of antibiotic resistance were highest in the poorest countries.
The study tracked more than 13,000 patients in 66 countries including UK.
Experimental Drug Kills Flu Virus in a Single Day – Science Alert – 13-Feb-2018
Shionogi claims its influenza virus treatment is faster-acting than any other flu drug.
One dose of baloxavir marboxil effectively kills the virus within a single day.
Overall time to alleviate symptoms was similar to other anti-virals.
But faster relief might curb the virus’s contagiousness.
Oral drug works by preventing cells’ susceptibility to virus infection.
Phase 3 clinical trial completed in 2017.
Expecting approval in Japan this year, and US next year.
New antibiotic family discovered in dirt – BBC News – 13-Feb-2018
Gene sequencing analysed more than 1,000 US soil samples.
Compounds, called malacidins, annihilate several bacterial diseases.
Eliminated MRSA infected skin wounds in rats.
New antibiotic only treats gram-positive infections.
Drug-resistant diseases kill around 700,000 people a year.
Cancer-hunting nanorobots can shrink tumours – Independent – 13-Feb-18
Nanobots made from origami-folded DNA sheets.
DNA sheets contain blood-clotting drugs to shut off the blood supply to tumours.
Molecule release trigger responds to a chemical signature on the outside of cancer cells.
Could deliver toxic chemotherapy drugs with less side effects.
Doubled the life expectancy of non-treated mice.
Strategy can be used for many types of solid tumour cancers.
How do you build a healthy city? – The Guardian – 11-Feb-2018
Copenhagen aspires to be one of the healthiest cities in the world.
E.g. making it attractive to cycle, serving nutritious lunches in its institutions.
Special garbage bins designed for easy use when cycling.
Offers free stress clinics for anyone who needs them.
To make changes in public health you need a long perspective.
Healthy thriving people are more likely to complete an education and find employment.
Hundreds of fire deaths may be linked to skin creams – BBC News – 11-Feb-2018
Some skin creams containing paraffin, a senior firefighter warns.
If used regularly paraffin residue can soak into the fabric .
Acts as an accelerant when it comes into contact with a cigarette or a flame.
Most creams do not carry warnings despite the risk.
Long-Lived Bats Have Telomeres That Don’t Shorten – Inverse – 7-Feb-2018
These mouse-sized mammals live way longer than they should.
Some of the telomeres of Myotis bats do not shorten as they age.
As well as genes for telomerase, they have 21 other telomere maintenance genes.
Like humans, don’t express telomerase in their blood cells.
Flocks of nanorobots could form artificial muscles – Chemistry World – 7-Feb-2018
DNA nanobots can already perform complex tasks.
Biomolecular motors designed to form tightly packed swarms forming lines or circles.
The robots are modified microtubules around 25nm in diameter.
After an hour five million microtubules will have formed swarms.
Able to turn off and on with UV light.
Very hot tea increases risk of oesophageal cancer – The Guardian – 5-Feb-2018
Cancer was already linked to drinking alcohol and smoking.
Risks are heightened by daily cups of burning hot tea.
Western tea drinkers tend to do so at lower temperatures.
15% 5-year survival rate for oesophageal cancer in the UK.
Chinese researchers studied nearly half a million people for nine years.
Quest to cure ageing like a disease – BBC News – 5-Feb-2018
Listen to recent episode of the BBC Tomorrow’s World podcast.
Discoveries suggest biological ageing may be entirely preventable and treatable.
Stem cell therapy provides tissue with replacements for cells that die during ageing.
New approaches may give patients an extra 30 years or so of life.
By then De Grey hopes the therapies could be reapplied as version 2.0.
8 things more likely to kill you in 1970s – BBC News – 4-Feb-2018
Eight things more likely to kill you in 1970s Britain than today.
2. The workplace
4. Britain’s roads
6. Cardiovascular disease
8. Lung cancer
Traumatic brain injuries linked to dementia risks – Science Nordic – 4-Feb-2018
Traumatic brain injury (TBI) can come from falling, contact sports, traffic accidents or violence.
Swedish register searched for all cases of brain trauma and dementia from 1964 to 2012.
TBI sufferers compared with people who did not suffer such head injuries.
Link with dementia was more frequent the more severe the injury.
Occurrence of early dementia is 200–400 times more frequent among professional boxers.
Infectious disease outbreak could kill 30 million people in a year – Business Insider – 2-Feb-2018
Global Health Security Agenda program is coming ot an end.
Bill Gates has described an emergent infectious disease as among the greatest threats humanity faces at the moment.
Epidemiologists say a fast-moving airborne pathogen could kill more than 30 million people in less than a year.
The risk of a global pandemic hasn’t fallen over the past five years.
Practical hair regeneration technology – Phys – 2-Feb-2018
New method for the mass preparation of hair follicle germs (HFGs).
Study reports the successful preparation of up to 5000 HFGs simultaneously.
Used oxygen-permeable dimethylpolysiloxane (PDMS) as substrate material for culture vessel.
Confirmed hair generation at back and scalp transplantation sites on mice.
DeepMind develops AI to diagnose eye diseases – Financial Times – 1-Feb-2018
Crunched data from thousands of retinal scans to train an AI algorithm.
Analyses them for signs of glaucoma, diabetic retinopathy and AMD.
Detects signs of eye disease more quickly and efficiently than human specialists.
Two-year partnership with NHS and London’s Moorfields Eye Hospital.
The technology could enter clinical trials in a few years.
Tiny Magnetic Hammer Drives Through Brain Tissue – Spectrum – 29-Jan-2018
Millirobots responds to magnetic field generated by MRI scanners.
Bullet-shaped robot produces enough force to drive it into animal brains.
Contains a stainless-steel bead that is pulled back and forth.
Bead compresses a mechanical spring in one direction.
MRI machines’ magnetic field orientation is fixed, limiting directional control.
Could performing minor medical interventions, e.g. piercing a cyst and biopsies.
Handheld device sequences human genome – BBC News – 29-Jan-2018
Handheld device developed by the company Oxford Nanopore.
Nanopore tech analyser uses longer strands of DNA.
Can read parts of the genome not seen before including telomeres.
Patient benefits also depend how fast we can make sense of the genomic.