Want to live forever? Join the club!
Join the growing number of people who are committed to living forever. Now that healthcare has merged with IT the exponential growth in medical technology means immortality may be closer than you think. From drug research and diagnostics to exoskeletons and nanobots – rapid advances are increasing our life expectancy every day.
Radical life extension is a growing industry – and more and more people are putting (a lot!) of money where their mouths are:
- 5 billionaires who want to live forever – Fortune Magazine
- Understanding Calico: Larry Page, Google Ventures, and the quest for immortality – The Verge
- Oracle founder Larry Ellison has proclaimed his wish to live forever and donated more than $430 million to anti-aging research. – Washington Post
Synthetic stem cells offer benefits without the risks – Kurzweil AI – 13-Jan-2017
First synthetic version of a cardiac stem cell created.
Cannot replicate – reducing risk if tumor growth and immune rejection.
More durable than human stem cells – can tolerate harsh freezing and thawing.
In vitro experiment on mouse cardiac tissue promoted growth after a heart attack.
Craig Venter talks through his new Health Nucleus clinic – Aging Reversed (YouTube) – 13-Jan-2017
The new approach to healthcare:
Life threatening diseases discovered in 40% of clinic visits who thought they were 100% healthy,.
Machine learning can predict face model from genome alone.
Personalised medicine boost as cancer drug monitored in real-time – Chemistry World – 13-Jan-2017
Aptamer-based sensors can track levels of small molecules in mobile rats.
Could continuously guide drug dosing in humans by monitoring drug metabolism or organ function.
Whole blood tended to foul up sensors’ molecular sites.
New sensors have laminar flow sheath passes above the sensor architecture, allowing small molecules through but washes blood cells away.
Eat hot peppers for a longer life – Science Daily – 13-Jan-2017
Consumption of hot red chili peppers is associated with a 13 percent reduction in total mortality.
Reduction in deaths primarily from fall in heart disease or stroke.
Transient Receptor Potential channels may in part be responsible for the observed relationship.
Capsaicin plays a role in cellular and molecular mechanisms that prevent obesity and modulate coronary blood flow.
Study used NHANES III data of over 16,000 Americans – median follow-up of 18.9 years
Digital health pharma news from Q4 2016 – MobiHealthNews – 13-Jan-2017
Investment in digital tools to enhance data collection in clinical trials.
Litmus Health using wearable devices to test the effects of activity, sleep, and diet on Inflammatory Bowel Disease (IBD) patients.
VeriTrova biomarker analysis leveraging technology to reduce normal analysis time from months to weeks.
FDA cleared the wireless integration of LifeScan’s blood glucose monitoring systems and WellDoc’s digital diabetes management platform.
Senseonics working on a long-term implantable continuous glucose monitor called Eversense.
Science-Backed Therapy Targeting Senescent Cells May Be Future Anti-Aging Serum – Medical Daily – 11-Jan-2017
Growing older results in a build-up of the body’s senescent cells and naturally accumulate with age.
Senior rodents given therapy that removed these cells lived 25 percent longer and were able to regrow hair, run faster, and had improved organ function.
A perfect anti-senescence therapy would also kick-start tissue rejuvenation by stimulating differentiation of nearby stem cells.
Stem cell research offers new hope of restoring sight – Medical News Today – 11-Jan-2017
End-stage retinal degeneration (e.g. age-related macular degeneration, retinitis pigmentosais) is the most common cause of irreversible vision loss and blindness in older adults.
Researchers transplanted stem cell-derived retinal tissues into animals with end-stage retinal degeneration.
Reprogrammed adult mouse skin cells into induced pluripotent stem cells which were then converted into retinal tissue.
Cells formed photoreceptors and directly contacted neighboring cells within the retina.
Procedure restored sight in almost half of the mice.
Study explains how western diet leads to overeating and obesity – Medical Xpress – 11-Jan-2017
Chronic consumption of a western diet leads to overeating and obesity due to elevations in peripheral endocannabinoid signaling.
Endocannabinoid system is located throughout the mammalian body, including the brain and all peripheral organs.
Participates in the control of many physiological functions in the body, including food intake, energy balance, and reward.
Targeting cannabinoid receptors with pharmacological inhibitors that do not reach the brain could be a safe therapeutic approach for the treatment of overeating and diet-induced obesity.
DARPA Has Huge Things Planned in Biotech – Futurism – 10-Jan-2016
In April 2014, DARPA established the Biological Technologies Office.
BTO have been doing work in areas such as memory improvement, human-machine symbiosis, and how to speed up disease detection and response.
Living Foundries project aims to develop programmable microbes able to produce compounds needed to develop medications on the fly.
Weekend-only workouts ‘still give an important health boost’ – NHS – 10-Jan-16
Any activity reduces risk of death from any cause or cardiovascular disease.
Weekend only activity had no significant effect on reducing cancer risk – unlike “insufficiently active” group.
Study of 64,000 participants with an average age of 58.6 years.
COMMENT: reaffirms that regular movement, however small, is better than long periods of inactivity with a few big bursts.
9 things you can do to live longer and fight ageing – Independent – 9-Jan-2016
French surgeon and personality Michel Cymes puts together a twist on the usual list.
Includes eat more garlic, clean your fridge, invest in good sunglasses and change your pillow.
Stop feeling guilty for not being perfect.
Surgeons label 3D printing technology ‘revolutionary’ (VIDEO) – BBC – 6-Jan-2016
Cyclist lost jaw in an accident.
Rebuilt using bone from shoulder and titanium metal plate.
Used 3D printed model to plan operation and make bespoke teeth implants.
COMMENT: amazing – looking at the patient in the video I can barely notice an injury now
Qatar leading ‘ambitious’ genome project in Gulf – Gulf Times – 6-Jan-2017
Qatar Genome Programme (QGP) focuses on mapping the population as well as treating common and rare diseases.
Pilot phase has seen sequencing of 3,000 genomes of Qatari nationals.
Sequencing genomes of 10% of the population is good enough to generate enough data that could be applied on the entire population of a nation.
In collaboration with Pathway towards Personalised Medicine (PPM) to encourage local research on genomics.
Rapamycin may slow aging – Cosmetic Surgery Times – 3-Jan-2017
Increases lifespan of mice by the equivalent of 10 human years.
Rapamycin is an immunosuppressant, anti-fungal and anti-cancer macrolide compound
Binds and inhibits the activation of the mammalian Target Of Rapamycin (mTOR).
Already used in humans as a transplant rejection inhibitor, therapy for renal cell carcinoma and as a stent coating.
Flow is a wearable air pollution tracker that might help you live longer – Wareable – 3-Jan-2017
Small memory stick-like dongle.
Crowdsources data with other devices to build a map of air quality.
Tracks PM2.5, NOx, Ozone and VOCs.
Glanceable LED interface as well as app.
The Flow will launch later this year, with a price yet to be announced.
We are vulnerable to flu epidemic in next decade – BBC – 30-Dec-2016
Bill Gates says the world is a bit vulnerable right now.
Ebola and Zika crises showed the systems for responding to emergencies are still not strong enough.
Dame Sally Davies (Chief Medical Officer for England): It would take at least six months from the start of a flu pandemic to get an effective vaccine.
Spice up your meals, live longer – Guardian – 29-Dec-2016
Curry,ginger, chili peppers help slow aggressive tumours growth.
Could also help to fight arthritis, diabetes.
Cancerous cells divided more slowly in cell cultures treated with capsaicin.
In another study of almost half a million people, participants who ate spicy foods almost every day had a relative 14 per cent lower risk of death (over 7 year study follow up period) compared to those who consumed spicy foods less than once a week.
Anti-aging therapies targeting senescent cells: Facts and fiction – Cell – 29-Dec-2016
Peter de Keizer of the Erasmus University Medical Center discusses strategy of removing senescent cells.
Need to identify how senescence impairs tissue rejuvenation and design compounds that can both target senescence and stimulate rejuvenation in a safe manner.
Cell-penetrating peptides may provide promising therapeutics.
With anti-senescence therapies we are the furthest we have ever been on the path to healthspan extension and restoration of the loss of health experienced during aging.
Be Nice, Because People Who Care for Others Live Longer – TIME – 27-Dec-2016
Study of more than 500 people between ages 70 and 103.
Those who provided care for someone in their social network lived an average of 3 years longer than people who didn’t.
Positive emotions experienced from helping others may combat the negative effects of emotions like stress.
Full-time caregiving may cause more stress so striking a balance may be important.
Consistently enjoying life could make you live longer – Medical News Today – 27-Dec-2016
Earlier findings showed that enjoyment of life during a single moment in time was associated with a longer life.
University College London (UCL) researchers wanted to know how important is sustained well-being?
Enjoyment of life was assessed three times at 2-year intervals between 2002-2006.
Those people most enjoying life had 17% reduction in risk of death over 10 year study period.
Study included 9,365 adults with an average age of 63 years.
How to lengthen your healthy life – Knowridge Science Report – 26-Dec-2016
In summary – eat well, exercise regularly, get plenty of sleep, and stay away from bad habits.
Seventh-day Adventists have a life expectancy nearly 10 years longer on average than most Americans.
Their behaviors include regular exercise, a vegetarian diet, avoiding tobacco and alcohol, and maintaining a healthy weight.
Combination of different types of exercise—aerobic, strength and balance training, and flexibility—is important to healthy aging
Genes account for less than one-third of your chances of surviving to age 85.
Nanoarray sniffs out and distinguishes ‘breathprints’ of multiple diseases – Kurzweil AI – 23-Dec-2016
International team of scientists have identified a unique “breathprint” for 17 diseases with 86% accuracy.
Noninvasive, inexpensive, and miniaturized portable device screens breath samples to classify and diagnose several types of diseases.
Researchers analyzed breath samples collected from 1404 patients who were either healthy or had one of 17 different diseases.
Each disease produces a unique breathprint, based on differing amounts of 13 volatile organic chemical (VOC) components.
COMMENT: I’m often proclaiming the future of healthcare is precision medicine using a drop of blood – but using my breath would be even easier
Programming Stem Cells to Repair or Regenerate Damaged Cells – A4M – 20-Dec-2016
Scientists from Penn State have uncovered the cellular mechanisms that control the programming of the stem cells.
Will help researchers develop methods to use stem cells to generate other cell types through direct programming.
Technique could eventually be used to repair or regenerate damaged cells in the body
This Robotic Suit Wants to Make Your Grandparents Superpowered – Motherboard – 20-Dec-2016
Superflex developing consumer-level approach to the exosuit – AKA powered clothing – lightweight and discreet.
Natural movement is supplemented by an extra, powered push.
Shame and stigma around using a cane or a walker is strong.
But we don’t see the person who’s electing not to go out.
Raised a $9.6 million Series A round – aiming to hit the market in mid-2018.