Want to live forever? Join the club!
Join the growing number of people who are committed to living forever. Now that healthcare has merged with IT the exponential growth in medical technology means immortality may be closer than you think. From drug research and diagnostics to exoskeletons and nanobots – rapid advances are increasing our life expectancy every day.
Radical life extension is a growing industry – and more and more people are putting (a lot!) of money where their mouths are:
- 5 billionaires who want to live forever – Fortune Magazine
- Understanding Calico: Larry Page, Google Ventures, and the quest for immortality – The Verge
- Oracle founder Larry Ellison has proclaimed his wish to live forever and donated more than $430 million to anti-aging research. – Washington Post
17 new genes linked to longer lifespan identified – Times Now News – 8-Nov-2017
A team of researchers have discovered 17 new genes linked to longer lifespan, which they say could one day be targeted to help prolong human life.
The team studied 389,166 volunteers who took part in the UK Biobank, with confirmation in the US Health and Retirement Study and the Wisconsin Longitudinal Study.
The study found evidence to suggest that the genetic variants for average lifespan also influence exceptionally long life expectancy.
Key to Diseases in Mitochondrial DNA Mutations – Longevity Facts – 6-Dec-2017
DNA sequences between mitochondria inside a single cell are vastly different.
Mitochondrial dysfunction has been linked to type 2 diabetes, Parkinson’s, Alzheimer’s and cardiovascular disease.
Mitochondrial DNA (mtDNA) is only inherited from your mother.
UPenn researchers isolated a single mitochondrion and then extracted its DNA.
Will only the rich cheat death? – Marketplace – 5-Dec-2017
Some of the biggest names in tech are on a quest to live forever.
Amazon’s Jeff Bezos, Oracle’s Larry Ellison and Google’s Larry Page and Sergey Brin have invested a lot of money in life-extension technologies, including cryogenics and digitizing our minds and uploading them into robots.
Race to create body parts in the lab – The Guardian – 5-Dec-2017
Decellurised scaffold is basted in patient stem cells, called mesoangioblasts.
Bioreactor pumps in nutrients and cells begin to form a tube of smooth muscle.
Then need to place under the skin to vascularise it.
Ultimate goal is to make synthetic organs from scratch using a synthetic scaffold.
Virtual Artery improves prediction of treatment side-effects – European Commission – 5-Dec-2017
Multiscale computer model incorporates data from physics, chemistry and biology.
Replicates single cell activity in the arterial wall and in the flowing blood.
Model verified against in vitro tests that stretched strips of tunica media.
High performance computing is the game-changer.
Aim is to take data from an individual patient and generate predicted health outcomes.
New Brain Interface Reveals Details on Visual System – RD Mag – 4-Dec-2017
Super-Nyquist density EEG captures higher spatial resolution than ever before.
Provides information from the visual cortex than the four standard “Nyquist density” versions.
Should improve location detection such as source of seizures in epilepsy.
Pol III enzyme shows anti-aging potential – New Atlas – 4-Dec-2017
RNA polymerase III (Pol III) is an enzyme essential for cell growth.
Found withinin almost all cells across all mammals.
The enzyme negatively impacts stem cell function, gut health and survival.
10 percent lifespan extension seen in yeast, flies and worms when inhibited.
FDA approves cancer-gene profiling test – Chron – 2-Dec-2017
Foundation Medicine’s test for patients with advanced or widely spread cancers.
FoundationOne CDx tests for 324 genes in any solid tumor.
Tests may point to studies testing drugs that target those genes.
Avoids multiple tests for individual genes that match specific drugs.
Antibiotic resistance expected to reduce life expectancy – Telegraph – 1-Dec-2017
Antibiotic resistance has caused a fall in life expectancy for the first time, the Office for National Statistics has said.
Under the projection made in 2010, a baby girl born in 2016 could expect to live 83.7 years. This has now been revised down to 82.9.
Life expectancy for babies born in 2060, the latest year which appears in both models, is now two years shorter than it was in the 2010 data.
Startup raises $114 million to reverse type 1 diabetes – Business Insider – 30-Nov-17
Semma Therapeutics is looking to use stem cells to regulate blood sugar level.
For some type 1 diabetes patients the condition is caused when body mistakenly kills beta cells found in the pancreas.
Embryonic stem cells are grown into beta cells.
Delivered via implant under a patient’s skin.
New UK map of air pollution provides insights into NO2 levels – Science Daily – 30-Nov-2017
MappAir® is the first ever high resolution nationwide map of air pollution.
Combining data from satellites and its own air quality monitoring sensors together with open source data, EarthSense has used complex modelling techniques to create the highly accurate map
MappAir® can provide a street-view to city-wide visualisation of air pollution, and is the first in a series of nationwide products that are coming to market in the next year.
BGRF & Oxford University launch The Longevity Podcast – Eurek Alert – 30-NOV-2017
The Biogerontology Research Foundation announces the launch of The Biogerontology Research Foundation announces the launch of The Longevity Podcast, a podcast produced in partnership with the Oxford University Scientific Society.
The purpose of the project will be to discuss the latest scientific advancements, as well as provide an introduction to the science of life extension in an easy and accessible way.
Unnatural microbe can make proteins – BBC News – 29-Nov-2017
Bacterium’s DNA modified to incorporate six letters instead of four.
E. coli bug could hold on to the synthetic code.
Proteins created contained “unnatural” amino acids.
No loss of efficiency compared with natural protein synthesis.
Novel proteins could form basis of new treatments and novel materials.
Wearable sensor combines ECG and optical heart rate monitoring – Mobi Health News – 29-Nov-2017
Silicon Labs has announced a new line of optical biometric sensors.
Lower power consumption for consumer-grade wearables.
Device could run continuously reducing need to recharge or turn off.
Module includes a motion-compensating heart rate algorithm.
COMMENT: Expect to see in branded devices in 2018?
The Lab of the Future: AI and Microfluidics – Technology Networks – 27-Nov-17
Integration of robotics and automation has revolutionized procedures.
Microfluidics enables the analysis of extremely small fluid volumes.
Able to house multiple experiments on a single chip.
Liquid handling robots are capable of processing thousands of samples.
Machine learning enables interrogation of both unstructured and structured data.
Virgin birth stem cells tested for first time – New Scientist – 27-Nov-2017
“Virgin birth” stem cells come from unfertilised eggs.
Parthenogenetic cells avoid the ethical issue around embryonic stem cells.
The cells have been injected into the brains of people with Parkinson’s disease
Theoretically could create or treat any part of the body.
Glasgow has UK’s highest death rate – Belfast Telegraph – 27-Nov-2017
Glasgow has topped the list of places with the highest mortality rate in the UK, new data has revealed.
The city recorded 1,389.1 deaths per 100,000 people last year, against a UK average of 982.5.
Apart from the City of London, the London borough of Kensington and Chelsea had the lowest mortality rate of any area of the UK, with just 667.4 deaths per 100,000.
Military tests brain implants that change your mood – IB Times – 27-Nov-2017
DARPA is funding research into “mind control” chips.
Closed loop brain implants use artificial intelligence to detect mood disorders.
Electric shocks automatically jolt a person’s brain back to a healthy state.
Shocks can also improve performance in some tasks.
Already tested on 6 patients with epilepsy.
Ethical concerns that technology exposes person’s inner feelings.
40g of cheese a day may be good for health – NHS – 4-Nov-2017
10% reduction in the risk of cardiovascular diseases.
Biggest reduction in risk came from around 40g – a matchbox sized piece.
Cheese is a good source of dietary vitamins, minerals and protein.
Meta-analysis study of of more than 34,000 people.