Want to live forever? Join the club!
Join the growing number of people who are committed to living forever. Now that healthcare has merged with IT the exponential growth in medical technology means immortality may be closer than you think. From drug research and diagnostics to exoskeletons and nanobots – rapid advances are increasing our life expectancy every day.
Radical life extension is a growing industry – and more and more people are putting (a lot!) of money where their mouths are:
- 5 billionaires who want to live forever – Fortune Magazine
- Understanding Calico: Larry Page, Google Ventures, and the quest for immortality – The Verge
- Oracle founder Larry Ellison has proclaimed his wish to live forever and donated more than $430 million to anti-aging research. – Washington Post
Smartphone ‘orders’ body to treat diabetes using optogenetics – BBC News – 29-Apr-2017
Smartphone used to control blood sugar levels in mice with diabetes.
Mice were genetically engineered to manufacture drugs that control blood sugar levels in response to light
Could be applied to a wide range of diseases and drug treatments.
9 Computational Drug Discovery Startups Using AI – Nanalyze – 25-Apr-2017
Including BenevolentAI which already has 24 drug candidates.
98% of big data has only been created in the last several years.
Cloud computing becoming cheaper and cheaper.
Also helped by emergence of deep learning algorithms.
Eating aged cheese could help you live longer – Independent – 25-Apr-2017
Aged cheeses like cheddar, brie and parmesan contain a compound, spermidine, which stops damaged liver cells from replicating.
Spermidine prevents accumulation of scar tissue caused by disease of the organ including the most common form of liver cancer.
Consuming foods like mushrooms, soya, legumes and whole grains regularly can also have the same life-extending effects.
Elon Musk wants to enhance us as superhuman cyborgs – Kurzweil AI – 21-Apr-2017
Neuralink would allow for radically improved communication between people.
Digital tertiary layer to augment the brain’s current cortex and limbic layers.
At the least it should lead to some exciting neuroscience breakthroughs.
Musk is concerned that either a small group of people monopolize AI power, or the AI goes rogue.
It’s not clear how we could be assured our brains aren’t hacked, spied on, and controlled by a repressive government or by other humans.
Researchers discover how protein aggregation triggers aging – News-Medical.Net – 21-Apr-2017
The insulin receptor acts like a brake on life expectancy.
Genetically altered animals where it no longer functions live much longer than normal.
Protein CHIP plays a crucial role in acting like a disposal helper.
When CHIP is missing, it leads to premature aging.
Unfortunatley if there is too much CHIP, undamaged proteins are also recycled and the organism is weakened.
Researchers by the universities of Cologne and Bonn published in the journal “Cell”.
Experts excited by brain wonder-drug – BBC News – 20-Apr-2017
Drug may stop all neurodegenerative brain diseases, including dementia and Alzheimer’s disease.
Already safely used in people – Trazodone taken by patients with depression and DBM is being tested in cancer patients.
Hoping to start human clinical trials on dementia patients soon.
AI Versus Aging – LEAF – 18-Apr-2017
Interview with Dr. Alex Zhavoronkov, CEO of Insilico Medicine
Company awarded the ‘Most Promising Company’ title at Personalised Medicine World Conference in 2015.
In 5 years we want to build a comprehensive system to model and monitor the human health status and rapidly correct any deviations.
Main breakthroughs expected in the area of multi-modal biomarkers of aging.
“Applying AI to aging is the only way to bring it under the comprehensive medical control.”
Alphabet’s Verily offers Study Watch health monitoring wearable – TechCrunch – 14-Apr-2017
Designed with long-term medical research in mind.
Will be used for Baseline – a study to track the long-term vitals of 175 individuals.
Contains multiple physiological and environmental sensors.
Designed to measure electrocardiogram (ECG), heart rate, electrodermal activity, inertial movements and more.
Tricorder X Prize winner announced – MobiHealthNews – 13-Apr-2017
Final Frontier Medical Devices wins $2.6 million prize after beating 255 teams that registered back in 2012.
Handheld device must continuously monitor five vital signs, diagnose 13 disease states and be usable by anyone.
FDA worked with the X Prize Foundation to provide a dedicated help desk for participants.
An Hour of Running May Add 7 Hours to Your Life – New York Times – 12-April-2017
2 hours running per week for 40 years adds up to about 6 months.
But expectancy increases by 3.2 years so a net gain of about 2.8 years.
Whatever someone’s pace or mileage, running reduced risk of premature death by almost 40 percent.
Smaller effect seen in walking, cycling and other activities.
Billionaire Jim Mellon invests in anti-ageing research firm – pharmaphorum – 11-Apr-2017
Insilico Medicine applying big data analytics to extend healthy longevity.
pursuing internal drug discovery in cancer, Parkinson’s, Alzheimer’s, sarcopenia and in geroprotectors.
Investment will fund validation of the many molecules discovered using machine learning.
Company has published studies including minute changes in gene expression between young and old tissues.
Artificial Thymus to Create Cancer-Fighting Cells – Futurism – 10-Apr-2017
T-cells mature within this gland.
People with some types of cancer are not getting the biological support and help they need from their T cells.
Also, nw adoptive T cell immunotherapy treatments depend on the patient having enough of these cells.
UCLA researchers have created artificial thymic organoids that create T cells from blood stem cells.
Able to produce cancer-specific T cells.
Prolonging Life with Fecal Transplants – Josh Mitteldorf – 10-Apr-2017
Middle-aged fish receiving a transplant of gut bacteria from young fish had in increased mean lifespan of 41%.
Fish that received young transplants were more active and showed more exploratory behavior later in life.
Loss of diversity is one of the ways that the gut microbiome is known to change with age.
Gut microbiomes vary widely but different sets of bacteria are able to perform similar services.
Fecal transplants are being studied as possible treatments for ulcerative colitis, IBS, type 2 diabetes and obesity.
Can Flossing Help You Live Longer? – Health Central – 30-Mar-2017
Good dental health may have direct effect on the heart and cardiovascular system.
According to study published in the Journal of the American Heart Association.
Gum disease is associated with a 12% higher risk of earlier death in older women.
Study involved more than 57,000 women 55 and older.
Is This the Anti-Aging Pill We’ve All Been Waiting For? – MIT Technology Review – 28-Mar-2017
Novartis sought to see whether giving low doses of everolimus to people over 65 increased their response to flu vaccines.
Called the “first human aging trial” as it looked at whether the immune system of elderly people could be made to act younger.
Startup resTORbio is licensing two drug molecules for aging-related disease.
Will further test whether such drugs can rejuvenate aged immune cells.
Everolimus is a derivative of rapamycin – which makes mice live 25% longer.
Adidas releases beta version of All Day, an app to track all aspects of wellness – MobiHealthNews – 28-Mar-2017
Offers customizable workouts, meal plans, mindfulness exercises and sleep tracking.
Pairs with Apple Health Kit and Google Fit to handle all that data.
Apps to support exercise or diet don’t need to be narrow in their focus.
Geroprotectors: Magnesium – LEAF – 26-Mar-2017
Not everyone gets enough of this essential element which is vital for cellular processes.
The daily intake of magnesium should around 300 mg for women and 400 mg for men.
Cocoa, dark chocolate, bananas, dark leafy greens, avocados, sesame seed, dried fruit, nuts and dates are all rich sources.
Magnesium deficiency can contribute to hypertension and diabetes as well as affecting cardiovascular health.
Hallmark of Aging Reversed by Senescent Cell Removal – LEAF – 25-Mar-17
Study directly targets one of the mechanisms that senescent cells use to avoid apoptosis,
Focused on FOXO4 (Forkhead box protein O4) and its influence on p53 gene.
Senescent cells increase expression of FOXO4 to escape apoptosis.
New approach potentially has fewer side effects.