At the Longevity Summit Dublin 2024, Jana Buzkova, co-founder of NADMED, presented a keynote on the accurate and practical measurement of NAD+ in blood. Her team developed a breakthrough technology for real-time NAD+ measurement, applied in both clinical trials and healthy individuals. Buzkova highlighted the importance of understanding personal NAD+ levels before supplementing, as excessive NAD+ could lead to negative metabolic effects, such as insulin resistance. Her work emphasizes the need for personalized approaches in NAD+ supplementation​.

Key Points:

• NAD+ Measurement Technology: Jana Buzkova introduced a new technology developed by her company, NADMED, for measuring NAD+ levels in blood. This technology allows for easy, real-time measurement of NAD+ without the need for sophisticated equipment.
• NAD+ in Mitochondrial Disease: Buzkova’s team conducted clinical trials on mitochondrial myopathy patients, showing that NAD+ supplementation with niacin increased NAD+ levels in blood and muscle, leading to health improvements.
• NAD+ Reference Range: NADMED established a reference range for NAD+ levels in healthy individuals, providing a baseline for comparison in clinical and personal health settings.
• NAD+ Boosters in Healthy People: In trials with healthy individuals, Buzkova’s research found that while NAD+ levels increase with supplementation, they reach a saturation point. Going beyond this point may correlate with negative effects on glucose metabolism.
• Potential Negative Effects: Excessive NAD+ supplementation was linked to increased insulin resistance and glucose levels, and may pose a risk for cardiovascular disease.
• Practical Applications: Buzkova emphasized the importance of personalized NAD+ measurements before taking supplements and urged caution with high-dose NAD+ boosters, noting the lack of long-term safety studies.