Our research seeks to identify the mode of action of two “age-essential” micronutrients, lipoic acid (LA) and acetyl-Lcarnitine (ALCAR).

Our work has shown that ALCAR and LA improve two of the most important cellular lesions of aging: the inability to respond to oxidative and toxicological challenges and the loss of mitochondrial function. We are currently exploring why these stress response mechanisms decline with age and are particularly focusing on cellular signaling pathways that LA may induce to activate Nrf2-mediated gene expression.