Nature Structural & Molecular Biology is a monthly peer-reviewed scientific journal publishing research articles, reviews, news, and commentaries in structural and molecular biology, with an emphasis on papers that further a "functional and mechanistic understanding of how molecular components in a biological process work together".

It is published by the Nature Portfolio and was established in 1994 under the title Nature Structural Biology, obtaining its current title in January 2004.

5-year Impact Factor: 12.650