The central scientific interest of the Chien lab is to understand heart development at the molecular and cellular level, with the ultimate goal of applying the developmental principles, logic, pathways, technology, and model systems to unravel human heart disease.

Our research group plans to provide new insight into several areas of human cardiogenesis, ranging from molecular decoding of human heart development to developing completely novel technologies to control gene expression in the intact heart in vivo.

Professor Chien's lab is split jointly between the Solna (CMB) and the Huddinge (ICMC) campuses at Karolinska Institutet. Although the two labs act as one, CMB focuses primarily on molecular biology, while ICMC is more translational research. This arrangement gives the Chien lab a unique advantage in the field of regenerative cardiology.