Haiyuan Yu is a Tisch University Professor in Computational Biology at Cornell University's College of Agriculture and Life Sciences (CALS). His research primarily focuses on biomedical systems biology, using high-throughput experimental techniques and integrative computational methods to address complex biological problems. His interests span quantitative systems biology, statistical genetics, comparative genomics, and the application of machine learning in understanding disease mechanisms.

Professor Yu is especially known for investigating protein-protein interaction networks and their relevance in human diseases, as well as employing cutting-edge computational approaches to uncover biological insights. His work often challenges conventional principles in the field, such as the "guilt-by-association" assumption in disease inheritance models.