One of the most promising areas of research. If we can replace our stem cells then they can replace our aging cells.
More info coming soon.
World’s First Commercial iPSC Cell Plant Opens – The Scientis – 23-Mar-2018
Will produce cells derived from iPS cells for commercial applications.
Existing iPSC production facilities have only made cells available to researchers.
Will use induced pluripotent stem cells produced at Kyoto University.
Three zones will produce different types of cells to treat hundreds of patients per year.
Construction of the center cost approximately 3.6 billion yen ($342.7 million USD)
Macular degeneration reversed with stem cell treatment – BBC News – 19-Mar-2018
Major step towards curing age-related macular degeneration.
Human embryo cells were grown into a patch and inserted into the back of the eye.
The living patch is only one layer of cells thick and 6mm x 4mm area.
Stem cell patch repairs failed retinal pigment epithelium.;
AMD is the most common form of blindness in the UK.
Two patients took part in trial at Moorfields Eye Hospital in London.
Peter Diamandis launches new $250 million stem cells company – Tech Crunch – 15-Feb-2018
Celularity is a spinout from Celgene, a global biopharmaceutical company.
Hopes to use stem cells from placenta to regenerate tissue and organs.
Several clinical trials conducted – next step is FDA approval.
Approximately four million human placentas are disposed of per year in U.S. hospitals.
“Our ultimate mission is to make 100 years old the new 60” – Peter Diamandis.
Curing the incurable with regenerative medicine – The News Minute – 15-Dec-2017
Multiple Sclerosis (MS) patient regains ability to walk with stem cell therapy.
Indian start-up Advancells is working to bring this new form of medicine to the masses.
Contemporary medicine doesn’t really treat a disease.
Advancells produces stem cells for the treatments of various diseases.
Costing is on the quantity of cells that a patient will need.
Virgin birth stem cells tested for first time – New Scientist – 27-Nov-2017
“Virgin birth” stem cells come from unfertilised eggs.
Parthenogenetic cells avoid the ethical issue around embryonic stem cells.
The cells have been injected into the brains of people with Parkinson’s disease
Theoretically could create or treat any part of the body.
Brain Stem Cell Injections Slow Ageing In Mice – Sciencr – 24-Oct-2017
Natural stem cell loss in hypothalamus was closely correlated with ageing changes.
When stem cells destoryed in younger mice they displayed premature signs of ageing.
Implanted youthful hypothalamic stem cells made middle-aged animals live longer.
Implantation only worked when the genetically engineered to be resistant to inflammation.
Stem Cell Transplants Trialed for Age-Related Frailty – Fight Aging – 17-Oct-2017
Mesenchymal stem cells grown and engineered for transplantation with minimal risk.
Reduction seen in chronic inflammation that accompanies old age.
Cells typically don’t last long following transplantation, and thus it is the brief signaling changes that must produce benefits that can last for months or longer.
COMMENT: so if you’re under 45 it might be worth storing some of your youthful stem cells now for future use
New Type of Stem Cells Could Lead to New Treatments – Futurism – 12-Oct-2017
Researchers create Expanded Potential Stem Cells (EPSCs) in mice.
ES and iPS aren’t capable of growing into every type of cell.
EPSCs are able to produce all three types of blastocyst stem cells
The research has great implications for human regenerative medicine.
Charlatans threaten stem cell research with unproven cures – The Guardian – 4-Oct-2017
Stem cell research, or regenerative medicine, has great potential and has already delivered some breakthroughs, but its future is threatened by poor science, unrealistic hopes, unclear funding models and unscrupulous private clinics, they say in the Lancet medical journal.
Charlatans and dodgy clinics peddling unproven cures for diseases, according to a group of eminent scientists in the field.
FDA Cracks Down on Stem Cell Clinics – NY Times – 28-Aug-17
The F.D.A. reported actions against two large stem cell clinics and a biotech company calling them “unscrupulous actors” in regenerative medicine.
This clinics used to extract stem cells from bone marrow, blood or fat and develop into many different types of cells in order to repair or replace tissue damaged by disease, injury or aging.
But so far, the F.D.A. has approved only a few stem-cell products.
The F.D.A. commissioner Dr. Scott Gottlieb announced that there is no proof that these methods are actually work.
As a result of stem cell treatment in one of these clinics one woman went blind and two others suffered severe, permanent eye damage.
Forever Labs will bank your stem cells for future use – Digital Trends – 19-Aug-2017
The number and therapeutic quality of our stem cells diminishes with age.
Storing them will preserve them for future use such as combating disease and aging.
Stem cells are collected from your blood marrow – whole process takes around 15 minutes.
Procedure gives a five to 10 second pressure-like sensation and does not leave scars.
Company offers to “grow and bank your cells for $2,500”.
Then an extra $250 every year for storing your cells, or a flat fee of $7,000 for life.
Stem cell brain implants could slow ageing – The Guardian – 26-Jul-2017
Implanted stem cells that make fresh neurons in the brain. Lives of older mice extended by 0-15% compared to untreated animals. Natural production of neural stem cells slows down dramatically in adults. Planning to create supplies of human neural stem cells in the lab for clinical trials.
Reducing Inflammation Enhances Tissue Regeneration in Stem Cell Therapies – LEAF Science -22-Jul-2017
With aging the immune response becomes deregulated and inflammation becomes excessive. Improving healing by reducing the numbers of more aggressive and inflammatory types of macrophages present at the site of injury appears to be a viable approach. Researchers hoped to inject stem cells into an injury site to encourage regeneration. Suppressing inflammation with an anti-inflammatory drug improved the survival of transplanted stem cells.
Peter Diamandis – Longevity Escape Velocity – Aging Reversed – 6-Jun-17
Interesting interview with Peter Diamandis – founder of the X Prize Foundation and Singularity University. Many billionaires are getting annual placenta stem cell transfusions – and feel better for it. Placental mesenchymal stem cells (MSCs) do not trigger recipients immune system.
Patient uses fat stem cells to repair his wrist – CNN – 22-May-2017
Patient had no cartilage in wrist so joint was bone-on-bone and constantly inflamed.
Developed cysts and holes in the bones of his wrist.
Received an injection of stem cells from his own fat tissue.
Stem cells derived from adipose tissue are particularly good at becoming cartilage and bone.
MRI scan shows cysts are gone, the bone has restructured, and he formed new cartilage.
Lab-Grown Blood Stem Cells Produced at Last – Scientific American – 18-May-2017
One team reprogrammed skin cell derived iPS cells with seven transcription factors.
Progenitor cells are tantalizingly close to natural haemopoetic blood stem cells.
Another team used four transcription factors to directly convert cells from the lining of blood vessels.
Aimed at patients who need bone-marrow transplants, but could also prevent depletion as we age.
New Form of Stem-Cell Engineering Raises Ethical Questions – New York Times – 21-Mar-2017
Synthetic embryos could be assembled from stem cells that can organize themselves into embryolike structures.
Known as “synthetic human entities with embryolike features” — Sheefs, for short.
Soon we will learn how to engineer stem cells into new kinds of tissues and organs – and maybe eventually an entire human being.
Stem cells collected from fat may have use in anti-aging treatments – EurekAlert! – 17-Feb-2017
Adult stem cells collected directly from human fat are more stable than other cells.
Adipose-derived stem cells (ASCs) able to replicate and maintain their stability.
The rate at which these ASCs multiply stays consistent with age.
ASCs are not currently approved for direct use by the Food and Drug Administration.
Induced pluripotent stem cells don’t increase genetic mutations – Science Daily – 7-Feb-2017
iPSCs treatments have been slowed by concerns that these cells are prone to increased numbers of genetic mutations.
New research suggests that iPSCs do not develop more mutations than cells that are duplicated by subcloning.
Finding suggests that most mutations in iPSCs are not generated during the reprogramming but are rare genetic variants inherited from the parent skin cells.
Stem cell research offers new hope of restoring sight – Medical News Today – 11-Jan-2017
End-stage retinal degeneration (e.g. age-related macular degeneration, retinitis pigmentosais) is the most common cause of irreversible vision loss and blindness in older adults.
Researchers transplanted stem cell-derived retinal tissues into animals with end-stage retinal degeneration.
Reprogrammed adult mouse skin cells into induced pluripotent stem cells which were then converted into retinal tissue.
Cells formed photoreceptors and directly contacted neighboring cells within the retina.
Procedure restored sight in almost half of the mice.
Programming Stem Cells to Repair or Regenerate Damaged Cells – A4M – 20-Dec-2016
Scientists from Penn State have uncovered the cellular mechanisms that control the programming of the stem cells.
Will help researchers develop methods to use stem cells to generate other cell types through direct programming.
Technique could eventually be used to repair or regenerate damaged cells in the body
Anti-ageing breakthrough: Reprogramming the body could extend lifespan – Independent – 15-Dec-2016
Previous attempts resulted in younger cells but the mice developed tumours.
Salk Institute Salk researchers changed the way four genes were expressed for a short period, instead of totally reverting to stem cells.
Maintained the cell’s identity while reversing age-associated hallmarks.
Ageing has plasticity and might be reversed.
They also reported positive results in tests on human cells in the laboratory.
COMMENT: We’re on the verge of a rejuvenation revolution
Looking Back and Ahead in the Use of Pluripotent Stem Cells in Medicine – Fight Aging – 14-Dec-2016
Therapies that deliver fresh new stem cell populations will take up the work of lost cells, e.g. muscle cells in order to reduce frailty.
Stem cell decline in aging is driven by changes in signaling in tissue.
Replacing stem cell populations will probably be of only limited benefit without other rejuvenation therapies to reduce the burden of damage.
Stem cell tourism may end your life – Labiotech – 8-Sep-2016
Desperate patients are ready to do everything to access to new treatments.
Easily misled by headlines reporting early stage successes.
Quantitative and qualitative inconstancy in products availability worldwide.
European Committee for Advanced Therapy (CAT) has raised concern about absence of rigorous scientific and ethical requirements.
variability even within Europe where many products only authorized in individual nations.
Deaths and serious complications have occured in Germany and Italy.
No stem cells required – Kurzweil AI – 29-Apr-2016
Gladstone Institutes has used chemicals to transform human skin cells into heart cells.
97% of cells began beating like healthy heart cells.
Similar approach created neural stem-cell-like cells from mouse skin cells.
When transplanted the cells spontaneously developed into neurons, oligodendrocytes and astrocytes.
Could lead to regenerating lost or damaged cells directly with pharmaceutical drugs.
Dental Fillings Heal Teeth With Stem Cells – Newsweek – 7-Apr-2016
New filling stimulates stem cells to encourage the growth of dentin — the bony material that makes up the majority of the tooth.
Current treatment involves drilling out the decay and putting in a filling.
COMMENT: We’ll soon look back at root canal treatment the same way as we look back a medieval dentists.
Stem-cell repair system can regenerate any kind of human tissue – Kurzweil AI – 6-Apr-2016
Able to regenerate any tissue damaged by injury, disease, or aging.
University of New South Wales (UNSW Australia) researchers use similar method used by salamanders to regenerate limbs
System reprograms bone and fat cells into induced multipotent stem cells (iMS).
Successfully demonstrated in mice.
Human trials are planned next year.
Algorithm Predict How To Grow Any Cell Type – Longevity Reporter – 30-Jan-2016
Direct reprogramming signals a cell to morph straight into another cell type.
Alternative to embryonic and induced pluripotent stem cells.
University of Bristol have created ‘Mogrify’ – an atlas of chemical codes required.
Succeeded the first time for two new human cell conversions.
Do Current Stem Cell Therapies Produce Rejuvenation? – Fight Aging – 20-Jan-2016
Therapies available in clinics vary in type and quality of cells used.
Transplanted cells don’t survive for long but they alter the behavior of native cells.
But no current treatments could be classed as rejuvenation.
SENS model is for delivery of patient’s re-engineered stem cells with their age-related molecular damage removed.
First induced pluripotent stem cells 3D printer – The Herald – 21-oct-2015
Able to print extremely delicate iPS cells in three dimensions without damaging their biological functions.
Built by same researchers at Heriot-Watt University who developed first 3D stem cell printer which could only handle embryonic stem cells.
Next step is to make miniature 3D human tissues for drug testing which would be a more reliable alternative to live animal testing.
Stem Cell Transplants Extend Life in Rats – Fight Aging! – 31-Aug-2015
Monthly intravenous stem cells transplantations extend life span of rats by 31.3%.
Specific mechanisms unknown but likely related to better molecular signalling leading to better operation and maintenance of native cells and tissues.
Don’t tell me some rich person isn’t trying this on themselves somewhere!