Biological Age

Chronological age isn’t necessarily the same as cellular age. A middle-aged person may have a biological age of plus or minus 15 years.

  • biological age is a better indicator of future health
  • dozens of different aging markers study – including glycan, telomere length and methylation patterns
  • different parts of body can age at different rates
  • brains of older people who exercise regularly look 10 years younger
  • looking older could be a sign of an underlying disease

Identify where and how you are aging so you can target your anti-aging strategy and employ the most appropriate rejuvenation treatments.

Resources

NHS – Check your heart age

Insilico Medicine – Enter your blood test data to determine your age

Latest News

Aging tests yield varying results – Science Daily – 15-Nov-2017
1,000 people studied extensively from birth to age 38.
Telomere length did not predict physical or cognitive changes.
Different epigenetic clocks kept time with each other, but not predictive.
Collection of physiological measures found a stronger signal.
Aging happens at different rates in different tissues of the body.

Why Some People Age Faster Than Others – Newsweek – 11-Nov-2017
Genetic pathway identified that may regulate the rate at which we age.
Longevity and behavioral aging aren’t necessarily related processes.
C. elegans show diverse age-related declines in virility, pharyngeal pumping, and locomotion.
Variation in neuropeptide-mediated glia–neuron signalling modulates the rate of ageing.

‘USC Longevity’ app predicts how long you’ll live – Korea Biomed – 31-Oct-2017
USC researchers have developed a mobile application that will predict how long you’ll live.
The app is based on clinical biomarkers, socio-demographics and health behaviors developed from data on 20,000 U.S. adults aged 18 and over.
USC Longevity predicts current life expectancy, provides incentives adoption of a healthy lifestyle to improve life expectancy and help in financial planning.

Childhood poverty may up pregnant woman’s biological age – Business Standard – 17-Oct-2017
Researchers at The Ohio State University in the US examined blood from pregnant women to evaluate the length of telomeres. Shorter telomeres mean an older cellular age.
The researchers also asked the mothers-to-be about stressors, including low socioeconomic status and trauma during their childhood and current social support.
They found that women who reported low socioeconomic status as kids and who struggled with family support as adults were biologically older.

How your blood may predict your future health – The Guardian – 10-Oct-2017
Can predict life expectancy with reasonable accuracy based on diet, exercise, smoking and alcohol habits.
Analysis focused on measuring fibrinogen and C-reactive protein (CRP).
These inflammation are the body’s response to infections, stress and other harmful stimuli.
Differences in the levels of CRP and fibrinogen between socioeconomic groups begin to show relatively early in life.
Blood samples were gathered from nearly 8,000 adults.
General lack of research focusing on people in midlife.

Human Pancreas Reveals Signatures of Aging – Cell – 28-Sep-2017
Accumulated genetic and epigenetic errors eventually lead to impaired organ function.
2,544 human pancreas single-cell transcriptions analysied from eight donors over six decades of life.
Cells from older donors display increased levels of transcriptional noise.

Nucleolus is a life expectancy predictor – Phys – 31-Aug-2017
The nucleolus is a major structure in a cell’s nucleus responsilbe for ribosome biogenesis.
Max Planck Institute for Biology of Ageing has discovered a link between its size and life expectancy.
Biomarker found in study of long-lived roundworm Caenorhabditis elegans mutants.
Mutants showed smaller nucleoli than their shorter-lived relatives.
Size link was independent of the pathway that led to their longevity.
Molecules within the nucleolus could causally impact life expectancy.
Effect also seen in human muscle biopsies.

Epimorphy Sells “My DNAge” Biological Age Kit – The Scientist – 2-Aug-2017
Based on an epigenetic clock origianlly developed by Steve Horvath in 2013.
Biomarker measures analyses methylation levels at more than 2,000 CpG sites.
Proportion of chromosomes that are methylated increases with age.
Epimorphy is the direct to consumer (DTC) company of Zymo Research.
Urine or blood test kit costs USD$299.
Not yet FDA-approved, so the company cannot provide any health-related information.

New method to accurately determine functional age of cells – News Medical – 11-Jul-17
Considers biophysical qualities of cells, such as cell movements and structural features.
Other methods work at DNA or tissue level.
Examined dermal cells taken from people between the ages of 2 to 96.
Could help evaluate health effects and improve other treatments.

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