Chronological age isn’t necessarily the same as cellular age. A middle-aged person may have a biological age of plus or minus 15 years.
- biological age is a better indicator of future health
- dozens of different aging markers study – including glycan, telomere length and methylation patterns
- different parts of body can age at different rates
- brains of older people who exercise regularly look 10 years younger
- looking older could be a sign of an underlying disease
Identify where and how you are aging so you can target your anti-aging strategy and employ the most appropriate rejuvenation treatments. View an infographic.
NHS – Check your heart age
Insilico Medicine – Enter your blood test data to determine your age
Protein Patterns of Ill Health – The Scientist – 2-Aug-2018
Certain sets of proteins are associated with common conditions of aging.
Blood samples taken from over five thousand of elderly Icelanders.
Measured 4,137 known and predicted serum proteins within the samples.
Found 27 distinct networks, or modules, of proteins across the cohort.
Many of the networks were associated with specific complex diseases.
Also revealed patterns of expression associated with overall mortality.
Size Of Nucleolus Might Predict Lifespan – Inverse – 21-May-2018
Nucleolus is in the center of the cell’s nucleus.
It is where the cell’s protein-making machines — the ribosomes — are made.
Size of the nucleolus can determine the rate that a cell ages.
Organisms with smaller nucleoli tend to live longer.
NCL-1 — a gene linked to nucleolus regulation — may play a role.
Accelerated aging diseases have bigger nucleoli and more ribosomes.
Can’t say for sure yet whether the link is cause-and-effect.
Using AI to Predict Biological Age – Geneng News – 30-Mar-2018
Physical activity data from wearables can produce digital biomarkers of aging.
AI-based algorithm created by GERO outperformed previously available models.
Produced a separate deep CNN for mortality risks prediction.
Life and health insurance programs already provide discounts based on physical activity.
Major Biological Difference Between Generations – Science Alert – 22-Mar-2018
We seem to be ageing more slowly than we were two decades ago.
Biological age is lower for recent periods across all age groups.
Biggest drop (4 years) seen in men aged 60-79.
Biomarkers examined included inflammation, organ function and breath capacity.
Also blood indicators such as haemoglobin, cholesterol, creatinine and C-reactive protein.
Studied data of 21,575 under 80s in US between 1988 and 2010.
Your Pee May Reveal Your True Biological Age – Live Science – 27-Feb-2018
Natural chemical in urine appears in higher concentrations as we age.
8-oxoGsn is a byproduct of slow, lifelong damage to RNA.
Deterioration of RNA would be a proxy for measuring aging.
It is a well-known byproduct of the oxidation of guanine.
More than 1,200 people between 2 and 90 years old were tested.
It’s easy to detect in urine.
MCP-1 A Potential Aging Biomarker – LEAF Science – 8-Jan-2018
Reliable and fast ways to assess biological age are needed to determine the outcome of potential interventions.
Lifespan studies are most reliable but this is costly and time-consuming.
Monocyte chemoattractant protein MCP-1/CCL2 is an important chemokine.
It recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation.
Circulating MCP-1 increased in an age-dependent manner in wild-type mice.
In humans with aortic stenosis, MCP-1 levels were significantly higher in frail individuals.
Aging tests yield varying results – Science Daily – 15-Nov-2017
1,000 people studied extensively from birth to age 38.
Telomere length did not predict physical or cognitive changes.
Different epigenetic clocks kept time with each other, but not predictive.
Collection of physiological measures found a stronger signal.
Aging happens at different rates in different tissues of the body.
Why Some People Age Faster Than Others – Newsweek – 11-Nov-2017
Genetic pathway identified that may regulate the rate at which we age.
Longevity and behavioral aging aren’t necessarily related processes.
C. elegans show diverse age-related declines in virility, pharyngeal pumping, and locomotion.
Variation in neuropeptide-mediated glia–neuron signalling modulates the rate of ageing.
‘USC Longevity’ app predicts how long you’ll live – Korea Biomed – 31-Oct-2017
USC researchers have developed a mobile application that will predict how long you’ll live.
The app is based on clinical biomarkers, socio-demographics and health behaviors developed from data on 20,000 U.S. adults aged 18 and over.
USC Longevity predicts current life expectancy, provides incentives adoption of a healthy lifestyle to improve life expectancy and help in financial planning.
Childhood poverty may up pregnant woman’s biological age – Business Standard – 17-Oct-2017
Researchers at The Ohio State University in the US examined blood from pregnant women to evaluate the length of telomeres. Shorter telomeres mean an older cellular age.
The researchers also asked the mothers-to-be about stressors, including low socioeconomic status and trauma during their childhood and current social support.
They found that women who reported low socioeconomic status as kids and who struggled with family support as adults were biologically older.
How your blood may predict your future health – The Guardian – 10-Oct-2017
Can predict life expectancy with reasonable accuracy based on diet, exercise, smoking and alcohol habits.
Analysis focused on measuring fibrinogen and C-reactive protein (CRP).
These inflammation are the body’s response to infections, stress and other harmful stimuli.
Differences in the levels of CRP and fibrinogen between socioeconomic groups begin to show relatively early in life.
Blood samples were gathered from nearly 8,000 adults.
General lack of research focusing on people in midlife.
Human Pancreas Reveals Signatures of Aging – Cell – 28-Sep-2017
Accumulated genetic and epigenetic errors eventually lead to impaired organ function.
2,544 human pancreas single-cell transcriptions analysied from eight donors over six decades of life.
Cells from older donors display increased levels of transcriptional noise.
Nucleolus is a life expectancy predictor – Phys – 31-Aug-2017
The nucleolus is a major structure in a cell’s nucleus responsilbe for ribosome biogenesis.
Max Planck Institute for Biology of Ageing has discovered a link between its size and life expectancy.
Biomarker found in study of long-lived roundworm Caenorhabditis elegans mutants.
Mutants showed smaller nucleoli than their shorter-lived relatives.
Size link was independent of the pathway that led to their longevity.
Molecules within the nucleolus could causally impact life expectancy.
Effect also seen in human muscle biopsies.
Epimorphy Sells “My DNAge” Biological Age Kit – The Scientist – 2-Aug-2017
Based on an epigenetic clock origianlly developed by Steve Horvath in 2013.
Biomarker measures analyses methylation levels at more than 2,000 CpG sites.
Proportion of chromosomes that are methylated increases with age.
Epimorphy is the direct to consumer (DTC) company of Zymo Research.
Urine or blood test kit costs USD$299.
Not yet FDA-approved, so the company cannot provide any health-related information.
New method to accurately determine functional age of cells – News Medical – 11-Jul-17
Considers biophysical qualities of cells, such as cell movements and structural features.
Other methods work at DNA or tissue level.
Examined dermal cells taken from people between the ages of 2 to 96.
Could help evaluate health effects and improve other treatments.