Even with a longer health-span, that is longer lives and longer active lives, I don’t think anyone imagines octogenarians playing golf and windsurfing but looking like their skin is about to fall off their bones. Appearance is important psychologically and also physically when you consider that the skin is the largest organ of the body providing protection against infection and helping control temperature.
Radical life extension advocates typically suggest that we will want to revert to our 20-something bodies, but in the meantime I’ll be tracking scientifically proven products that keep skin and hair healthy.
Youth Laboratories – Track wrinkles & Evaluate treatments
Mobile app considers biomarkers of your face ageing giving objective assessment of treatments and products.
What are skin serums? – Harvard Health – 12-Jun-2018
Serums are light, easily absorbed oil- or water-based liquids.
Skin serums are not moisturisers and can be applied before them.
Dr. Waldman recommends serums that contain vitamins C & E, and ferulic acid.
Intensive dose of ingredients can address common skin complaints.
Can prevent brown spots, reverse UV damage, and stimulate new collagen.
Tea polyphenols and resveratrol target wrinkles.
Dry skin benefits from vitamin E, niacinamide, and glycolic acid.
Price doesn’t seem to make much difference – check the ingredients.
Can Aging Genes Be Altered by a Face Cream? – Vogue – 21-Jul-2018
Environmental factors can affect the epigenome.
A gene for skin elasticity may power down by age 40.
Various companies attacking different pathways.
Biologique Recherche uses a peptide-powered formula.
Sisley’s serum acts on the enzyme linked to elastin.
Bader users stem-cell technology originally used for burns.
Avoiding controversy by making cosmetic, not medical, claims.
Interview with OneSkin Technologies CEO – Thrive Global – 25-Jun-18
Carolina Reis Oliveira’s startup mimics human tissues to understand how they age.
OneSkin’s mission is to reverse skin aging.
As a PhD student she focused on stem cell and tissue engineering.
Growing 3D human skin tissues from human cells in the lab.
Decreasing senescent cells in the skin promotes its rejuvenation.
Potential new cure found for baldness – BBC News – 9-May-2018
Osteoporosis drug had a dramatic effect on hair follicles in the lab.
Targets a protein that acts as a brake on hair growth.
Clinical trial needed to see if it is effective and safe in people.
Only two drugs are currently available to treat balding.
Why Does Hair Turn Gray? Scientists May Know – Newsweek – 4-May-2018
Melanocytes make melanin which gives our hair its colour.
Special stem cells then add melanocytes to new follicles.
MITF protein helps melanocytes to function.
MITF also represses the expression of innate immune genes.
Suggest a connection between viral infection and hair graying.
Aging Looks Are Not Just a Matter of Aesthetics – Leaf Science – 19-Apr-2018
Old people tend to have grey hair, wrinkled skin, and weak muscles.
Aesthetics are not the main problem of elderly looks.
Skin acts as a thermal regulator and barrier to reduce fluid loss.
It synthesizes vitamin D from cholesterol through sunlight exposure.
It is also the body’s first line of defence against foreign threats.
Do moisturisers really work? – BBC News – 3-Aug-2017
Moisturisers do help by supplying water to the skin and trapping it there.
Key ingredients in moisturisers are water, occlusives, humectants, emollients, and lactic acid.
In most cases, the choice comes down to subjective experience
Standard moisturisers don’t stop wrinkles or ageing.
Could age related muscle loss be preventable? – Fight Aging – 18-Jul-2017
Sarcopenia is a significant contribution to the frailty of later aging.
A few recent papers suggest that a fair degree of the total burden of sarcopenia is actually self-inflicted.
Muscle requires maintenance, most people give up on that work too early.
Typical diet of older individuals also has a reduced protein content.
Global Foundation for Human Aging Research Donates $50K Harvard Medical School – CISION – 21-Jun-17
Sinclair Lab studies the processes that drive aging and age-related diseases.
Doing impressive work on NMN — a molecule that appears to protect against DNA degradation.
Need to shift health care from symptom suppression to prevention and wellness.
Global Foundation for Human Aging Research’s goal is to improve healthspan for aging populations worldwide.
Common Antioxidant Could Slow Symptoms of Aging in Human Skin – University of Maryland – 30-May-17
Methylene blue improved physical, biochemical and genetic aging markers.
Appears to make fundamental, long-term changes to skin cells
Tested in cultured skin cells from healthy middle-aged donors.
Fibroblasts experienced a decrease in reactive oxygen species, a reduced rate of cell death and an increase in the rate of cell division.
3D simulated human skin model saw features typical of younger skin.
Is This the Anti-Aging Pill We’ve All Been Waiting For? – MIT Technology Review – 28-Mar-2017
Novartis sought to see whether giving low doses of everolimus to people over 65 increased their response to flu vaccines.
Called the “first human aging trial” as it looked at whether the immune system of elderly people could be made to act younger.
Startup resTORbio is licensing two drug molecules for aging-related disease.
Will further test whether such drugs can rejuvenate aged immune cells.
Everolimus is a derivative of rapamycin – which makes mice live 25% longer.
Fir extract could have anti-cancer and anti-aging properties – Medical Xpress – 28-Feb-17
Effects of Siberian fir terpenoids on senescent and human cancer cell lines studied at the genetic level.
Trademarked as Abisil, the drug based on Siberian fir terpenoids is now used externally for its anti-inflammatory, wound-healing, and anti-bacterial medicinal properties
Terpenoids are a class of hydrocarbons that are the principal component of gums, balsams, and essential oils.
Betulinic acid has demonstrated anti-bacterial, antimalarial, and anti-inflammatory properties, as well as cytotoxicity toward cancer cells.
Secret of youthful looks in ginger gene – BBC News – 29-Apr-2016
DNA mutations that protect the body from UV radiation can also lead to red hair.
Study Erasmus University Medical Centre identifies MC1R gene which is critical for making melanin.
COMMENT: this is only “perceived age” – not an improvement in life expectancy
Harvard professor believes anti-aging pill is only a few years away – Sydney Morning Herald – 3-Oct-15
If the greatest driver of disease in old age is old age itself, then why not find a cure for ageing.
David Sinclair has battled sceptics in the scientific community who claimed his work was fundamentally flawed, but now his research in journal Science shows resveratrol, a compound in red wine, prolongs lifespan and improves health in a variety of animals.
Test shows how old your body really is – BBC News – 7-Sep-2015
Biological age determined from signature of 150 genes’ behaviour.
Can predict longevity and cognitive decline.
Skin Rejuvenation with Non-Invasive Pulsed Electric Fields (PEF) – Nature.com – 12-May-2015
PEF treatment resulted in formation of microvasculature, secretion of new collagen and increased metabolic activity in treated skin. New epidermis proliferation can improve skin barrier function against infection and hazardous materials.
Skin is the largest organ in the body and degenerative skin diseases affect one third of individuals over the age of sixty.
Anti-aging drug may be just 5 years away – The Times of India – 21-May-2015
Scientists at the University of Birmingham who have identified the role of the enzyme 11beta-HSD1 in the degenerative effects of aging.
Enhanced Longevity by Ibuprofen, Conserved in Multiple Species, Occurs in Yeast through Inhibition of Tryptophan Import – PLOS Genetics – 18-Dec-14
Geneu launches DNA matched anti-ageing serum – The Telegraph – 30-Nov-14
AMPK gene can slow the aging process throughout the entire body – UCLA – 9-Sep-14
‘Proof’ Boots Protect & Perfect Intense Beauty Serum beats wrinkles – BBC News – 28-Apr-09