Life Extension

Information on extending life expectancy to allow technologies to catch up and stop and reverse aging for good. Focussing on new technologies and treatments aimed at radical life extension, rather than the improvements in treatments of diseases covered in the health section.

Particularly interested in increased health span rather than lifespan.

Life expectancy – published research and statistics including cause of death and mortality
Rejuvenation – new ways of repairing bodies including replacement organs
Anti-aging – focus on our appearance such as skin, hair and lifestyle
Fountains of youth – contenders for radical reduction or reversal of aging.

Resources

Alkahest – http://www.alkahest.com/
Developing therapies derived from blood and its components with a focus to improve vitality and function into old age.

Latest News

Frequently Asked Questions on the Ethics of Life Extension – IEET– 08-June-2017
Can be classified into three groups
1. Is it theoretically and technologically possible?
2. Desirability for the individual and the society.
3. What practical implications for public policy?

Researchers discover how protein aggregation triggers aging – News-Medical.Net – 21-Apr-2017
The insulin receptor acts like a brake on life expectancy.
Genetically altered animals where it no longer functions live much longer than normal.
Protein CHIP plays a crucial role in acting like a disposal helper.
When CHIP is missing, it leads to premature aging.
Unfortunatley if there is too much CHIP, undamaged proteins are also recycled and the organism is weakened.
Researchers by the universities of Cologne and Bonn published in the journal “Cell”.

Half-century old misconception removes limits on life extension – EurekAlert – 7-Feb-2017
Strehler-Mildvan (SM) correlation was reported in 1960.
It relates to the Mortality Rate Doubling Time (MRDT) and Initial Mortality Rate (IMR), two parameters of Gompertz mortality law
It says that if the mortality rate is reduced by any interventions at an earlier age, the MRDT goes down, i.e aging accelerates.
Biotech company Gero showed that SM correlation arises naturally as a degenerate manifold of Gompertz fit.
Correlation was indeed a pure fitting artifact.

END OF DEATH says leading researcher – Express – 1-Nov-2016
Aubrey de Grey speaking at technological Inman Connect conference.
By your 20s the regeneration of cells is outpaced by the death of cells leading to ageing.
Molecular and cellular damage will one day be a thing of the past.
Will be tackled with regenerative medicines such as stem cell and gene therapies coupled with drugs and vaccinations.
Modern pharmaceutical industry focussing its efforts on delaying diseases, rather than beating them.

Our Complicated Relationship to Longevity – LARB – 4-Oct-2016
Book review: Cracking the Aging Code by Josh Mitteldorf, Dorion Sagan
Extending life is not just about clever biologists finding miracle cures.
Life extension has already been happening — clean drinking water, vaccines and antibiotics.
Most of us are now reaching old age in better health than did our parents and grandparents.

Scenarios for the future of healthy life extension – London Futurists – 25-May-2016
Talk by London Futurists chair David Wood discussing:
– possible engineering disruptions of the medical field
– possible social and political disruptions relevant to life extension
– 50% probability that comprehensive rejuvenation therapies will be widely available by 2040
Saturday 25th June 2016, Birkbeck College, London
Book now!

Advance praise for The abolition of aging – David Wood – 23-May-2016
Due out in June – looking forward to reading this well researched book.
“a truly revolutionary book” – José Cordeiro, Founding Faculty at Singularity University
“clear-headed, pragmatic, open but rigorous ‘classical’ thinking applied to visionary speculations” – Giulio Prisco, Board Member, IEET
“serves as a clarion call for concerted involvement by everyone concerned about a better future for humanity” – Zoltan Istvan, US Presidential candidate
“summarizing the entire field in a fascinating read” – Alexey Turchin, Co-founder, Longevity Party (Russia)

Pharmacological Extension of Lifespan – IEET – 4-Mar-2016
Sample chapter from Maria Konovalenko’s Longevity Cookbook.
Different ways of trying to develop pharmaceuticals to combat aging:
Model organisms
Target-based screens
Unbiased screens
Mining existing compounds

Radical Life Extension can be Developed Quickly for the Mainstream – IEET – 7-Jan-2016
Interview with Didier Coeurnelle – cochair of Heales,  board of International Longevity Alliance (ILA) and lifelong member of Longecity.
Radical life extension therapies for everybody would be useful in social and economic terms.
Choice between an expensive pill with millions of clients and a gigantic unpopularity or a cheap drug for billions of patients and a gigantic popularity.

Switching off genes could extend lifespan by 60 per cent – Sydney Morning Herald – 12-Oct-2015
238 genes identified that, when silenced, increase the lifespan of yeast cells.
Half of these genes are also present in mammals.
Researchers examined 4698 strains of yeast, each with a single gene deletion.
Most impressive results from LOS1 gene.

A History of Life-Extensionism in the Twentieth Century – free eBook (and hardcopy on Amazon) – Ilia Stambler, PhD
Researcher at Bar Ilan University, Israel. His research focuses on the historical and social implications of aging and life extension research.

Genetic switch starts aging in animals – Science Daily – 23-Jul-2015
Worm signals to itslef to turn off cell tissues protective mechanisms, precisely at the onset of reproductive maturity, starting the decline of the adult animal. Happens over course of hours. Genetic switch is target for future research.

Metformin seeks approval for first life extension drug trial – City AM – 9-Jul-2015
Existing diabetes drug has been show to delay aging so researchers are now applying to the US Food and Drug Administration (FDA) to run a human trial (Targeting Aging with Metformin, or TAME). Would set precedent for anti-ageing drug.

Methuselah Mouse Prize (MPrize) – Methuselah Foundation – 2003 onwards
First prizes already given out but as of May 2015 there is still $1.4 million up for grabs.

Rhodiola rosea found to increase fruit fly lifespan by 24% on top of restricted calorie effect. – KurzweilAINetwork – 20-Jun-13

Turning human spare parts into exports  – KurzweilAINetwork – 13-Jun-13

 

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