Information on extending life expectancy to allow technologies to catch up and stop and reverse aging for good. Focussing on new technologies and treatments aimed at radical life extension, rather than the improvements in treatments of diseases covered in the health section.
Particularly interested in increased health span rather than lifespan.
Life expectancy – published research and statistics including cause of death and mortality
Rejuvenation – new ways of repairing bodies including replacement organs
Anti-aging – focus on our appearance such as skin, hair and lifestyle
Fountains of youth – contenders for radical reduction or reversal of aging.
Alkahest – http://www.alkahest.com/
Developing therapies derived from blood and its components with a focus to improve vitality and function into old age.
Summary of 800 Page State of Longevity Research Report – Singularity Hub -14-Feb-2018
Report produced by Biogerontology Research Foundation, Deep Knowledge Life Science, Aging Analytics Agency, and Longevity.International.
Healthcare systems aren’t ready for rapidly aging global population.
Two main streams of intervention with already promising results:
– understand the root causes of aging and stop them before damage accumulates
– rejuvenation biotechnology, i.e. repair and maintenance
Identified several technologies rapidly gaining steam:
– artificial intelligence in drug discovery, identifying longevity genes and personalized medicine
– senolytics, over 10 prospective candidates are already in the pipeline
– gene therapy can directly target the root of any pathology
Four additional volumes expected in 2018.
Gene in Worms Could Be Key to Longer Human Lifespan – The Cornell Daily Sun – 13-Feb-2018
Disabling the SET-26 gene’s function increased lifespan by nearly 20%.
SET-26 and SET-9 genes are associated with a longer and healthier life in C. elegans worms
Worms also appeared more robust, alert and resilient to stress as they aged.
SET-26 gene codes for a protein modulates how securely DNA is coiled.
SET-26 protein has a good homolog in humans.
BGRF & Oxford University launch The Longevity Podcast – Eurek Alert – 30-NOV-2017
The Biogerontology Research Foundation announces the launch of The Biogerontology Research Foundation announces the launch of The Longevity Podcast, a podcast produced in partnership with the Oxford University Scientific Society.
The purpose of the project will be to discuss the latest scientific advancements, as well as provide an introduction to the science of life extension in an easy and accessible way.
Healthy 90-years-olds have same gut microbiome as 30-year-olds – Eurek Alert – 11-Oct-2017
Researchers at Lawson Health Research Institute and Tianyi Health Science Institute studied the gut bacteria in a cohort of more than 1,000 Chinese individuals in a variety of age-ranges from 3 to over 100 years-old .
The aim is to bring novel microbiome diagnostic systems to populations, then use food and probiotics to try and improve biomarkers of health.
The main conclusion is that if you are ridiculously healthy and 90 years old, your gut microbiota is not that different from a healthy 30 year old in the same population.
Is Aging a Gut Instinct? – LEAF Science – 10-Oct-2017
Initial source of age-related inflammation could be gut microbiota.
As we age the gut microbiota increasingly favors pro-inflammatory activity.
When kept in a germ-free environment mice did not show any increase in age-related circulating pro-inflammatory cytokines.
Age-associated changes to the microbiota can be reversed by reducing the level of TNF circulating in the system.
It is quite possible to slow aging and extend life span – Bio Spectrum – 13-Sep-2017
Interesting interview with Prof Brian Kennedy appointed to lead ongoing efforts at the National University of Singapore.
“Reversing the aging process is still an open question that requires more research.”
Anti-Aging Pilot Studies Announced – LEAF science – 12-Sep-2017
Non-profit Betterhumans announced its intention to begin small-scale trials of senolytic therapies.
The aim is to remove toxic senescent cells from the body in a bid to address age-related diseases.
The organization found out that combination of dasatinib and quercetin, has enjoyed success in mice in a number of studies. It improved mouse health and, in some cases, even increased lifespan.
The pilot studies aim to find out whether it will have the same positive results to humans.
Ilia Stambler Publishes New Text on Longevity Promotion – IEET – 10-Sep-2017
Book considers the multidisciplinary aspects of longevity promotion
Including advocacy, historical, philosophical and scientific perspectives.
Available on Amazon.
Indoles In Bowel Responsible For Longer Healthier Lives – Medical Research – 22-Aug-2017
Study into role of microbiota (bacteria inside and on body) on health span of animals.
Widely divergent animals utilize indoles to regulate how well they age.
Indoles are aromatic heterocyclic organic compounds produced by a variety of bacteria.
Indole levels are dysregulated (dysbiosis) in people with chronic inflammatory diseases.
Frequently Asked Questions on the Ethics of Life Extension – IEET– 08-June-2017
Can be classified into three groups
1. Is it theoretically and technologically possible?
2. Desirability for the individual and the society.
3. What practical implications for public policy?
Researchers discover how protein aggregation triggers aging – News-Medical.Net – 21-Apr-2017
The insulin receptor acts like a brake on life expectancy.
Genetically altered animals where it no longer functions live much longer than normal.
Protein CHIP plays a crucial role in acting like a disposal helper.
When CHIP is missing, it leads to premature aging.
Unfortunatley if there is too much CHIP, undamaged proteins are also recycled and the organism is weakened.
Researchers by the universities of Cologne and Bonn published in the journal “Cell”.
Half-century old misconception removes limits on life extension – EurekAlert – 7-Feb-2017
Strehler-Mildvan (SM) correlation was reported in 1960.
It relates to the Mortality Rate Doubling Time (MRDT) and Initial Mortality Rate (IMR), two parameters of Gompertz mortality law
It says that if the mortality rate is reduced by any interventions at an earlier age, the MRDT goes down, i.e aging accelerates.
Biotech company Gero showed that SM correlation arises naturally as a degenerate manifold of Gompertz fit.
Correlation was indeed a pure fitting artifact.
END OF DEATH says leading researcher – Express – 1-Nov-2016
Aubrey de Grey speaking at technological Inman Connect conference.
By your 20s the regeneration of cells is outpaced by the death of cells leading to ageing.
Molecular and cellular damage will one day be a thing of the past.
Will be tackled with regenerative medicines such as stem cell and gene therapies coupled with drugs and vaccinations.
Modern pharmaceutical industry focussing its efforts on delaying diseases, rather than beating them.
Our Complicated Relationship to Longevity – LARB – 4-Oct-2016
Book review: Cracking the Aging Code by Josh Mitteldorf, Dorion Sagan
Extending life is not just about clever biologists finding miracle cures.
Life extension has already been happening — clean drinking water, vaccines and antibiotics.
Most of us are now reaching old age in better health than did our parents and grandparents.
Scenarios for the future of healthy life extension – London Futurists – 25-May-2016
Talk by London Futurists chair David Wood discussing:
– possible engineering disruptions of the medical field
– possible social and political disruptions relevant to life extension
– 50% probability that comprehensive rejuvenation therapies will be widely available by 2040
Saturday 25th June 2016, Birkbeck College, London
Advance praise for The abolition of aging – David Wood – 23-May-2016
Due out in June – looking forward to reading this well researched book.
“a truly revolutionary book” – José Cordeiro, Founding Faculty at Singularity University
“clear-headed, pragmatic, open but rigorous ‘classical’ thinking applied to visionary speculations” – Giulio Prisco, Board Member, IEET
“serves as a clarion call for concerted involvement by everyone concerned about a better future for humanity” – Zoltan Istvan, US Presidential candidate
“summarizing the entire field in a fascinating read” – Alexey Turchin, Co-founder, Longevity Party (Russia)
Pharmacological Extension of Lifespan – IEET – 4-Mar-2016
Sample chapter from Maria Konovalenko’s Longevity Cookbook.
Different ways of trying to develop pharmaceuticals to combat aging:
Mining existing compounds
Radical Life Extension can be Developed Quickly for the Mainstream – IEET – 7-Jan-2016
Interview with Didier Coeurnelle – cochair of Heales, board of International Longevity Alliance (ILA) and lifelong member of Longecity.
Radical life extension therapies for everybody would be useful in social and economic terms.
Choice between an expensive pill with millions of clients and a gigantic unpopularity or a cheap drug for billions of patients and a gigantic popularity.
Switching off genes could extend lifespan by 60 per cent – Sydney Morning Herald – 12-Oct-2015
238 genes identified that, when silenced, increase the lifespan of yeast cells.
Half of these genes are also present in mammals.
Researchers examined 4698 strains of yeast, each with a single gene deletion.
Most impressive results from LOS1 gene.
A History of Life-Extensionism in the Twentieth Century – free eBook (and hardcopy on Amazon) – Ilia Stambler, PhD
Researcher at Bar Ilan University, Israel. His research focuses on the historical and social implications of aging and life extension research.
Genetic switch starts aging in animals – Science Daily – 23-Jul-2015
Worm signals to itslef to turn off cell tissues protective mechanisms, precisely at the onset of reproductive maturity, starting the decline of the adult animal. Happens over course of hours. Genetic switch is target for future research.
Metformin seeks approval for first life extension drug trial – City AM – 9-Jul-2015
Existing diabetes drug has been show to delay aging so researchers are now applying to the US Food and Drug Administration (FDA) to run a human trial (Targeting Aging with Metformin, or TAME). Would set precedent for anti-ageing drug.
Methuselah Mouse Prize (MPrize) – Methuselah Foundation – 2003 onwards
First prizes already given out but as of May 2015 there is still $1.4 million up for grabs.
Rhodiola rosea found to increase fruit fly lifespan by 24% on top of restricted calorie effect. – KurzweilAINetwork – 20-Jun-13
Turning human spare parts into exports – KurzweilAINetwork – 13-Jun-13