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Geroprotectors: Creatine – LEAF – 16-May-17
Creatine is a small peptid and an important energy buffer in muscle cells.
The body produces approximately 1 gram of creatine per day.
Creatine is naturally-occurring in many foods, particularly meat and fish.
But cooking denatures it so difficult to get enough of it in your diet.
Has neuroprotective properties and may reduce brain lesions.
Applied as a cream creatine may restore skin elasticity and reduce wrinkles by replenishing collagen stores.

Geroprotectors: Magnesium – LEAF – 26-Mar-2017
Not everyone gets enough of this essential element which is vital for cellular processes.
The daily intake of magnesium should around 300 mg for women and 400 mg for men.
Cocoa, dark chocolate, bananas, dark leafy greens, avocados, sesame seed, dried fruit, nuts and dates are all rich sources.
Magnesium deficiency can contribute to hypertension and diabetes as well as affecting cardiovascular health.

Geroprotectors: Honokiol – LEAF – 21-Feb-2017
Honokiol is a lignan isolated from the bark, seed cones, and leaves of the trees of various Magnolia species.
Well documented antioxidant.
Inhibits inflammatory signals via the activation of the NF-kb protein complex.
Potential treatment for rheumatoid arthritis.
Further studies may be needed to ascertain its long term effects.

Geroprotectors: Glucosamine – LEAF – 19-Feb-2017
One of the most commonly used supplements frequently taken to promote joint health.
Glucosamine naturally occurs in cartilaginous joint tissues and is involved in protein and lipid synthesis.
Plenty of food sources but cooking denatures it so hard to get sufficient from diet alone.
Inhibits the NF-kB protein complex, a central mediator of inflammation and central to the aging process, especially when combined with chondroitin.
Studies have also shown a reduction of cancer mortality risk.
It may be worth considering as part of your health regimen.

Geroprotectors: Quercetin – LEAF – 31-Jan-2017
In various studies quercetin has demonstrated antioxidant, anti-bacterial, anti-inflammatory and anti-carcinogenic properties.
Quercetin is naturally found in some fruit and vegetables such as apples, onions and dark cherries.
But to get a typical dose (around 500mg) used for health purposes would mean eating at least fifty apples a day!
Quercetin is a naturally occurring member of the flavonoid family – a large family of water-soluble chemicals, which are not created by the body
Isoquercetin has the same benefits as regular quercetin has but has better bioavailability and absorption by the body.

Geroprotectors: Pterostilbene – LEAF – 28-Jan-2017
Pterostilbene has antioxidant, anti-inflammatory and anticarcinogenic properties.
Estimated content per blueberry varying between 99 ng to 520 ng – obtaining enough from dietary means isn’t really a realistic proposition.
Available as a dietary supplement from various suppliers.
Pterostilbene has increased bioavailability compared to resveratrol and other stilbene.
Increases sirtuins which are best known for their pro-longevity effects in dietary restriction experiments.

Ray Kurzweil talks about Physical Immortality  – Aging Reversed – 3-Jan-2017
Ray talks about the singularity, AI and human hybrid thinking with neocortex connected to the cloud.
Taking 90 supplement pills a day including metformin.
Phosphatidyylcholine  lipid makes up 90% of cell membranes at aged 10 – but this reduces with age meaning organs work less well.
Pills won’t make him live forever – but long enough for medical technology to find other ways to enable radical life extension.
We have 1000s time more renewable energy available to help with overpopulation problems.

Elysium Basis May Not Be What You Think It Is – Thrivous – 21-oct-2016
Has two active ingredients, Nicotinamide Riboside and Pterostilbene, aimed at cellular detoxification, DNA repair, and energy production.
Elysium is not the only company that sells NR to consumers.
Has formidable science advisory board and 30 peer-reviewed clinical studies.
None are studies of Nicotinamide Riboside or Pterostilbene supplementation on humans.
$50 per month for Elysium Basis probably is not the best investment of your supplement budget.

These six plant extracts could delay aging – Kurzweil AI  – 16-Sept-2016
Each targets a different anti-aging or pro-aging signaling pathway.
Health Canada classifies them as safe for human consumption
Most effective is Salix alba, more commonly known as white willow bark.
Study used  budding yeast Saccharomyces cerevisiae as its cellular aging model.
Plant extracts tested were:
Cimicifuga racemosa
Valeriana officinalis L.
Passiflora incarnata L.
Ginkgo biloba
Apium graveolens L.
Salix alba

Vitamin myths debunked: what should you be taking? – The Guardian – 14-Jun-2016
Sales of vitamins are higher than those of painkillers.
If you’re well with no symptoms and a reasonable diet, it’s very unlikely that you’ve got a significant vitamin deficiency.
The question is whether taking them will do you any harm.
Many of us will have lowish vitamin D levels after a long winter.
COMMENT: consider taking vitamin D supplements in the UK while the weather is so cloudy

Scientists Identify Plant Extracts That May Slow Down Ageing Process – Health Newsline – 17-Mar-2016
Found six new groups of molecules that decelerate the chronological ageing of yeast
Includes extract of Willow bark – nature’s aspirin – which increased lifespan of yeast by 400%.
Research by Concordia University and Idunn Technologies.
COMMENT: don’t expect such spectacular results in humans!

Aged garlic extract can reduce plaque buildup in arteries – Medical Xpress – 21-Jan-2016
LA BioMed research saw reduction in soft plaque in arteries.
Randomized study involved 55 patients with metabolic syndrome, i.e. at risk of developing cardiovascular disease, diabetes or stroke.
Total coronary plaque volume measured at atart and after 1 year.
Results showed reduced soft and low-attenuation plaque as well as slowed total plaque accumulation.
Study scheduled for publication in the Journal of Nutrition

Omega-3 supplements not as good as the real thing – Kurzweil AI – 26-Aug-2015
Some research suggests that a diet high in omega-3 fatty acids can protect brain health but a large clinical trial has found that omega-3 supplements do not slow cognitive decline in older people.

Effects of a Standardized Bacopa monnieri Extract on Cognitive Performance, Anxiety, and Depression in the Elderly – Journal of Alternative and Complementary Medicine – July-2008
Enhanced AVLT delayed word recall, improved depression scores and decreased heart rate compared to placebo.