Navigation using mental mind maps rejuvenated in old mice
Is is possible to rejuvenate tissues in the aging brain?
Could replace lost stem cells by transplanting them or or spurring them to divide.
Stimulating the small population of neural stem cells encouraged them to multiply.
New neurons survived and formed contacts with nearby neurons in old mice.
Old brains learn the movements needed to reach a destination rather than create a mental map.
Old mice recovered the ability to build mind maps.
Overexpression of cell cycle regulators Cdk4/cyclinD1 compensated for age-related decline in neurogenesis.
Researcher by the Center for Regenerative Therapies, TU Dresden, published in Nature Communications.