Is senescent cell clearance a zero sum game?
Physical results of senolytic treatments show they are doing a lot more good than harm.
Mice receiving thirteen rounds of senescent cell-clearing therapy still seeing benefits.
Removing senescent cells stops their secretions inhibiting progenitor cells’ regenerative function.
Some experiments do show a smaller impact of senolytics.
This is due to the failing supply of progenitor cells before treatment was initiated.
Solution is to pair senolytic with cell therapy to introduce new functional cells.