Biological age reversed with growth hormone and diabetes drugs cocktail
Trial was designed restore tissue in the thymus gland using growth hormone.
This hormone can also promote diabetes, so the trial included two anti-diabetic drugs.
Dehydroepiandrosterone (DHEA) and metformin are widely used.
Nine healthy volunteers took the drug cocktail for one year.
Participants, on average, shed 2.5 years of their biological ages based on their epigenetic clocks.
The effect persisted six months after stopping the trial.
Blood-cell count was rejuvenated and thymus tissue regenerated.
Expansion of immune cells also has implications infectious disease and cancer.
Thymus Regeneration, Immunorestoration and Insulin Mitigation (TRIIM) trial.
Findings by University of California, Los Angeles, were published in Aging Cell.
Caution warned: trial was small and did not include a control arm.