Molecular destruction code found in an enzyme involved in cholesterol synthesis
A key enzyme in the cholesterol synthesis pathway can be regulated and destroyed using a particular molecule.
Can be used to develop new drugs to lower cholesterol levels.
Cholesterol is mostly produced inside the human body, contribution from food is small.
The enzyme squalene monooxygenase in the cholesterol synthesis pathway has a destruction code.
Once the destruction code is unlocked a ubiquitin molecule can bind to it and destroy the enzyme.
Needs further research to unlock this code and to initiate enzyme destruction.
Research by University of New South Wales, published in the Journal of Biological Chemistry.