Drinkable molecule interferes with a crucial first step of Alzheimer’s
Binding of amyloid beta peptides to prion proteins triggers devastating events.
Yale screened tens of thousands of compounds for molecules that interfere with the interaction.
An old antibiotic was a promising candidate but only after decomposing to form a polymer.
Small polymers managed to pass through the blood-brain barrier.
In mice, synapses in the brains were repaired and lost memory recovered.
The next step is to verify the compounds aren’t toxic in preparation for clinical trials.