Senescent Cell Clearance

Senescent cell clearance could be one of the big treatments to at least slow down one of the underlying causes of aging.

Senescent cells have stopped dividing and, even worse, secrete tens of biologically active proteins, including pro-inflammatory factors, proteases, pro-fibrotic factors and growth factors. This Senescence Associated Secretory Phenotype (SASP) can induce senescence in neighbouring cells and is associated with many age-related diseases.

Draft page – more coming soon.

Latest News

Cellular aging halted by hydrogen sulfide gas – Medical News Today – 7-Aug-2018
University of Exeter targeted splicing factors within the mitochondria.
Used samples of endothelial cells that line the inside of blood vessels.
Team designed novel chemicals that targeted either SRSF2 or HNRNPD.
Compounds delivered a minute dose of hydrogen sulfide gas to mitochondria.
Gas fires up the splicing factors, giving mitochondria a boost.
Senescent cells in the sample dropped by an impressive 50 percent.

Cleara Biotech Joins the Race to Develop Senolytic Therapies – Leaf Science – 9-Jul-2018
Last year its drug candidate was effective while leaving healthy cells unharmed.
Removes senescent cells using interaction between FOXO4 and p53.
Apollo Ventures had been looking for a marker specific to senescent cells.
Cleara will spend the next year optimizing the peptide.
Aim to bring a safe, effective senolytic therapy into human clinical trials.

UNITY Treats First Patient with UBX0101 – UNITY Biotechnology – 25-Jun-2018
UNITY develops therapeutics to slow, halt or reverse diseases of aging.
Treated first patient in Phase 1 clinical trial evaluating UBX0101.
Patient suffers from moderate to severe osteoarthritis of the knee.
Osteoarthritis is one of the main reasons why it hurts to get old.
Treatment selectively eliminates senescent cells in the joints.
Phase 1 clinical trial of single ascending dose evaluates safety.

Gene that triggers senescence identified – Buffalo – 22-Jun-2018
University at Buffalo study illuminates genes involved in cellular senescence.
Gene called CD36 is unusually active in older, senescent cells.
Can stop young, healthy cells dividing by heightening CD36 activity.
Effect spread to nearby, untreated, cells.
COMMENT: it would be interesting to see what happens in old cells if CD36 was turned off

Escape from senescence boosts tumour growth – Nature – 20-Dec-2017
Senescence is usually thought to be irreversible.
Many anti-cancer therapies cause cancer-cell senescence.
Cells have a boosted capacity to drive tumour growth if they exit senescence.
cellular signalling pathways activated during chemotherapy-induced senescence are similar to the gene-expression patterns observed in stem cells.

To stay young, kill zombie cells – Nature – 24-Oct-2017
Proof-of-concept trials starting that pit senolytic drugs against a range of age-related ailments.
Senescent cells will probably need to be cleared only periodically.
Hit and run delivery could reduce the chance of side effects.
Dispatching most of them is enough to make a difference.
COMMENT: great history of cell senescence and its treatment

False Positives in Senescent Cell Detection – LEAF Science – 19-Aug-2017
Researchers commonly determine the presence of senescent cells through the use of the p16ink4a (p16) and β-galactosidase biomarkers.
May not be the only cells that exhibit both of these biomarkers.
Therapies target these too, removing cells that are not senescent.
Oisin Biotechnology does use p16 as a target biomarker.
Benefits may outweigh risk of removing non-senescent cells.

Planning Your Own Trial of Senolytic Drugs – Fight Aging! – 22-May-17
A guide for anyone considering self-experimentation.
Obtain a Cooperative Physician
Obtain a Cooperative Laboratory Company
Determine the Health Metrics to be Assessed
Pick the Senolytic Drug Candidates
Establish Dosage and Schedule
Figure out the Logistics
Determine Suppliers and Order Products
Test the Products
Run the Experiment

Treating Osteoarthritis by Removing Senescent Cells – LEAF – 3-May-2017
Researchers used local clearance of senescent cells (in mice) to reduce the development of post-traumatic osteoarthritis and encourage tissue regeneration.
Senescent cells accumulated in the articular cartilage and synovium after they induced anterior cruciate ligament injury.
Selective elimination of these cells reduced the development of osteoarthritis post injury, reduced pain and encouraged cartilage development.
Researchers used a compound called UBX0101 a senolytic drug created by Unity Biotechnology.

Hallmark of Aging Reversed by Senescent Cell Removal – LEAF – 25-Mar-17
Study directly targets one of the mechanisms that senescent cells use to avoid apoptosis,
Focused on FOXO4 (Forkhead box protein O4) and its influence on p53 gene.
Senescent cells increase expression of FOXO4 to escape apoptosis.
New approach potentially has fewer side effects.

New protein discovered in aging and cancer – Medical Xpress – 7-Mar-2017
Study describes a new way that senescent cells communicate via the expression of integrin membrane proteins.
Findings could one day lead to new treatments for ageing and early cancer.
A drug against integrin beta 3, called ‘cilengitide’, already exists that averts inflammation.

Science-Backed Therapy Targeting Senescent Cells May Be Future Anti-Aging Serum – Medical Daily – 11-Jan-2017
Growing older results in a build-up of the body’s senescent cells and naturally accumulate with age.
Senior rodents given therapy that removed these cells lived 25 percent longer and were able to regrow hair, run faster, and had improved organ function.
A perfect anti-senescence therapy would also kick-start tissue rejuvenation by stimulating differentiation of nearby stem cells.

Anti-aging therapies targeting senescent cells: Facts and fiction – Cell – 29-Dec-2016
Peter de Keizer of the Erasmus University Medical Center discusses strategy of removing senescent cells.
Need to identify how senescence impairs tissue rejuvenation and design compounds that can both target senescence and stimulate rejuvenation in a safe manner.
Cell-penetrating peptides may provide promising therapeutics.
With anti-senescence therapies we are the furthest we have ever been on the path to healthspan extension and restoration of the loss of health experienced during aging.

A Look at Ascendance Biomedical, Packaging Medical Tourism for Longevity Therapies – Fight Aging! – 28-Dec-2016
It is focused on the twofold path of
(a) establishing patient-funded trials of potentially useful therapies in the longevity science space
(b) packaging participation in trials and later purchase of therapies via medical tourism
The point is not Ascendance Biomedical today, it is the potential Ascendance Biomedical of a few years from now.

Targeting Senescent Cells with Synthetic Biology – LEAF – 9-Dec-2016
CellAge is going to develop synthetic promoters which are specific to senescent cells, as promoters that are currently being used to track senescent cells are simply not good enough to be used in therapies.
Can you join me in donating to this crowdfunding campaign?

This start-up believes it can slow the aging process – Washington Post – 28-Oct-2016
Unity Biotechnology’s technology jump starts senescent cells into dividing again.
Company has raised $116 million.
Human trials planned in the next 12-18 months will focus on eye diseases
Ned David: “we do expect people to live free of a variety of chronic diseases.”

Secret to old age health could lie in purging worn-out cells – New Scientist – 16-Sep-2015
Cells eventually stop dividing to replace damaged neighbours and to into senescence.
Senescent cells produce inflammatory chemicals that underlie many aging related diseases.
Drug tests in mice show marked single dose of drugs have long lasting rejuvenation effects.
You’ll need to buy the magazine or subscribe to read the full article.

Clearing the Body’s Retired Cells Slows Aging and Extends Life – The Atlantic – 3-Feb-2016
Cells accumulate damage in their DNA.
Eventually become senescent – i.e. they stop dividing – and are characterized by protein p16.
Team developed a way of singling out and removing those cells – increased lifespan of mice by a quarter.
Possibly “one of the more important aging discoveries ever.”
Have made an old organism physiologically younger – treatment instead of prevention.

Senolytics, A New Class Of Drugs, Slows Aging Process – Medical Daily -11-Mar-15