Digital Modeling

Virtual 3D models of the body and individual organs will allow us to test drugs and procedures faster than ever before with no harm to patients or animals.

 

Resources

Highest-resolution map of the entire human brain created – KurzweilAI – 16-Sept-2016
Digital human brain atlas allows researchers to investigate the structural basis of brain function.
Combines neuroimaging with cellular resolution histological analysis and expert structural mapping.
Digitized the histological data at true cellular microscopic resolution.
Allen Human Brain Reference Atlas is a freely accessible online resource – visit brain-map.org

Supercomputer simulates whole-body blood flow – BBC News – 17-Mar-2016
Uses a 3D representation of every artery that is 1mm across or wider.
Compares extremely well with real-world flow measurements
Aim is to test how different interventions in cardiovascular disease might affect the system more widely.
In future could simulate the progress of single cancer cells through the bloodstream.
COMMENT: and with a faster computer could be speeded up to see the impact over decades without having to wait

Virtual human body available online – New Scientist – 23-Sep-2015
Visible Human Project photographed 5000 slices of a cadaver.
Combined with extensive MRI and CT scans to create digital body.
High resolution model can be used for virtual experiments taking into account tissue parameters such as density and thermal conductivity.

Personalized heart models for surgical planning – Today’s Medical Developments – 21-Sep-2015
Converts MRI scans of a patient’s heart into a physical model within hours.
Surgeons able to assess and prepare for surgery taking into consideration the individual patient’s anatomical idiosyncrasies.
MIT graduate student Danielle Pace developed the software that analyzes the MRI scans.

Digital (virtual) 3D model of heart released – Today’s Medical Development’s (TMD) – 03-Jun-2015
Scientifically accurate, physics-based simulated heart will accelerate device testing and heart disease research.
Virtual reality examination inside massive heart projection!

in silico model of inflammatory response to traumatic injury – Medical Xpress – 11-May-2015
Simulates multiple factors that interact with each other in complex diseases.  Multiple markers of inflammation in trauma care patients’ blood samples enables model to predict hospital length of stay, multi-organ dysfunction and death rate.

Simulated Mouse Brain in a Virtual Mouse Body – Human Brain Project – 23-Feb-2015
Neurorobotics platform models simplified virtual mouse brain (200,000 neurons compared to 75 million) mapped to different parts of the mouse body, including the mouse’s spinal cord, whiskers, eyes and skin.

Virtual worm brain controls Lego robot (video) – Science Alert – 12-Dec-2014
OpenWorm project has mapped and simulated all the connections between the c. elegans
worm’s 302 neurons.
Reverses away from obstructions without a single line of code.

First steps towards a computer simulation of the human body – The Independent – 8-May-2014
University of Sheffield’s Insigneo Institute working on European Commission’s Virtual Physiological Human programme with ultimate aim to create a computer simulated replica of the human body (“in silico”). Individual patient’s data could be input into their virtual avatar to predict how their real body will react to drugs and other treatments.

Technical simulation models mechanics of human body – ScienceNordic – 13-Nov-2011
Able to determine how different exercises induce bone strain and strain rates. From a mechanical engineering point of view, humans are just like machines with complex geometry: instead of steel structures we have a skeletal system; instead of hydraulics we have a muscle system.
Model is now being used to research the causes of degenerative arthritis.

Computer Model Predicts Cardiac Effects of Drugs – JAMA – 31-Aug-2011
Predicts adverse effects of 2 drugs used to treat abnormal heart rhythm.
Models affect of ion channel–regulating drugs on the electrical signals in the heart.

Virtual drug tests – Bayer HealthCare – 2011
PK-Sim software predicts pharmacokinetic processes, such as the absorption, transport and metabolism of the active substance in whole-body ADME simulation. Database contains tens of thousands of existing substances, plus models of 15 organs.
Coagulation simulator models the effect of active ingredients on the blood-clotting process.

 

 

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