Diabetes

Diabetes is currently the 5th most common cause of death in the world.
5% of people (1 in 20) in the UK have diabetes.
Diabetes is the 7th leading cause of death in the US.

Around 1 in 8 people between 20 and 79 years old have their death attributed to diabetes.

The average life expectancy is reduced by:
More than 20 years (Type 1)
Up to 10 years (Type 2)

 

Latest News

‘Anti-aging’ hormone could unlock new treatments for kidney and heart disease – Medical Xpress – 13-Feb-2017
King’s College London has found that patients with diabetes suffering from the early stages of kidney disease have a deficiency of Klotho.
Klotho levels could be used as a risk marker to predict kidney disease.
Klotho protects the vascular system against changes associated with abnormal ageing.

Big data holds key to tackling diabetes – Scotsman – 21-Jan-2017
AXA Research Fund funding research aims to mine existing data sets (e.g. PCRs, wearable devices).
Patterns may predict risk of future complications.
Aims to identify disease pathways for personalised medicine.
Nearly 350 million people worldwide are affected by diabetes – and rising.
NHS spends around £10 billion each year treating the disease.

Smart patch that automatically delivers insulin when needed – Kurzweil AI – 20-Jan-2016
Skin patch covered in painless microneedles that are loaded with tiny insulin-carrying pouches.
Replaces finger-pricking and insulin shots .
Vesicles function as both glucose sensing element (GOx) and insulin release actuator/
Device has only been tested on mice so far.

Oxford researchers developing a diabetes breathalyzer – MobiHealthNews – 9-Nov-2016
University of Oxford are developing a portable non-invasive device to detect diabetes and monitor glucose levels.
Work-in-progress published in the American Chemical Society’s journal Analytical Chemistry
Uses an absorbent polymer that traps acetone from exhaled breath and then probes with a laser to determine its concentration.
Previous studies studies have found that elevated levels of acetone are found in the exhaled breath of diabetes patients.
Accuracy of the device tested under a range of conditions, e.g. after exercising, fasting overnight.

10-minute walk after a meal good for diabetes – NHS – 18-Oct-2016
Study compared 10-minute walk after a main meal to a single 30-minute walk each day.
Walking after a meal resulted in 12% lower blood glucose levels.
Low volume study: 41 adults (average age 60) who had diabetes for an average of 10 years.
Post-meal physical activity may avoid the need for an increased total insulin dose.

FDA Approves Automated Device to Manage Diabetes – Bioscience Technology – 29-Sep-2016
Patients with type-1 diabetes will no longer have to constantly check glucose levels.
Device from Medtronic automatically monitors glucose levels and administers the proper insulin dose.
Artificial pancreas measures glucose levels every five minutes.
MiniMed 670G is approved for type 1 diabetes patients 14 years and older.

Growing tiny stomachs to help diabetics produce their own insulin – STAT – 19-Feb-2016
Cells found in bottom of stomach particularly good to reprogram as insulin-producing cells.
Grew them into mini insulin-producing organs.
Glucose levels kept normal in 25% of recipient mice.

Promising cell therapy for diabetes hidden in seaweed bubble – STAT – 25-Jan-2016
In type 1 diabetes the immune system dismantles the pancreatic cells, known as beta cells, that normally produce insulin.
Can produce beta cells derived from donor human embryonic stem cells but are rejected.
Disguising them in alginate (a seaweed extract) allows sugar and insulin to flow between the cells and the body, but blocks immune cells.
Body eventually identifies material as a foreign substance, so MIT researchers tested 774 variations of alginate.
New alginate covered beta cells still working well 6 months after being transplanted into mice.
Next step is primate studies.

Technology increases life expectancy of diabetes patients – Diabetes.co.uk – 5-Oct-2015
Careful management of blood glucose levels as treatment of type 1 diabetes (T1D) enabled by technological advances in blood glucose meters, insulin pumps, smartphone apps and continuous glucose monitors (CGMs).
Refers to 2012 US study showing an increase of 15 years in life expectancy for those diagnosed 1965-1980 compared to those diagnosed 1950-1964.
However, type 1 diabetes is still associated with a shorter life expectancy than people without diabetes.
Study reference: Medical Journal of Australia

Google Takes Aim at Diabetes with Big Data – Health IT Analytics – 31-Aug-2015
Google was granted a patent for a contact lens that continuously measures a patient’s blood glucose in March of 2015.
New partnership with Joslin Diabetes Center and Sanofi could be ready to bring it to market.
Assume more miniaturized medical devices around the corner.

Smart insulin hope for diabetes – BBC News – 10-Feb-15
Automatically turns itself on and off to maintain correct blood glucose levels

Bionic pancreas in successful human trial – BBC News – 31-Aug-14
Mimics a real pancreas by delivering both insulin to lower blood sugar and glucagon to raise it.

 

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