Antibiotic Resistance

It’s almost unbelievable to think that antibiotics were discovered less than a century ago, and that before then people were severely disabled or killed by what we now regard as easily treatable diseases. Scientists have been warning for years that bacteria is slowly becoming resistant to our wonder cure and that there is no plan B when the last carefully controlled antibiotics no longer work.

Recently there has been a few stories of potential new forms which prevent us going bck to the dark ages so I’ll be monitoring developments of those here

 

Resources

WHO lists deadly bacteria in bid to push antibiotics R&D – LSIPR – 28-Feb-2017
12 families of bacteria which it claims pose the greatest threat to human health.
Antibiotic resistance is growing, and we are fast running out of treatment options

Dreaded Superbug Has Officially Arrived in the United States – IEET – 17-Nov-2016
US Centers for Disease Control has identified over a dozen cases of antibiotic-resistant fungus, Candida auris.
Four of the first seven patients infected with it have died.
Typically treated with a class of antifungal drugs called echinocandins but some now found to be resistant to all three major classes of medications.
Patients probably acquired their infections locally.
Candida auris can spread quite easily with traces found on patient’s mattress, furniture and windowsill.

Trading Modern Medicine for Cheap Meat – IEET – 3-Jun-2016
A superbug resistant to all known antibiotics has surfaced in the United States for the first time.
Rate of new antibiotic development has not kept pace with this growing problem.
Number of new antibiotic agents approved by the FDA has declined steadily over time.
In depth article discusses:
– Regulatory Hurdles
– Economic Hurdles
– Scientific Hurdles
– Antibiotic Misuse in Livestock Production and Policy Solutions

Bacteria resistant to antibiotic of last resort found in UK – BBC News – 21-Dec-2015
Colistin resistant bacteria discovered on three UK farms and in samples of human infections.
Present in almost 1 in a 1000 samples.
All resistant bacteria responsive to other antibiotics – but if mcr-1 gene is transferred to superbugs it will create infections that doctors cannot treat.
Antibiotic apocalypse threatens to plunge medicine back into the dark ages.

World on cusp of ‘post-antibiotic era’ – BBC News – 19-Nov-15
Common infections would kill once again, surgery and cancer therapies under threat.
Bacteria found in 20% of livestock in China that is resistant to drug of last resort – colistin.
Likely emerged after overuse in farm animals.
Hospitals now struggling to find an antibiotic for patients several times a month – almost unheard of only five years ago.

MIT engineers class of bacteria-destroying viruses – New Scientist – 7-Oct-2015
Timothy Lu at the Massachusetts Institute of Technology aim to make a single phage modifiable with bacteria-attacking machinery from other phages.
Phage viruses infect and replicate inside bacteria, killing them, so are a possible alternative to antibiotics – and are more selective.
Successfully modified phage that normally kills E. coli to kill Yersinia and Klebsiella bacteria.

Clinical trials for new class of anti-biotic – BBC News – 31-Aug-2015
Better and faster than best currently available drug for Clostridium difficile.
Strathclyde University also testing dozens of potential S-MGB anti-biotics that target different infectious organisms.

Researchers reverse bacterial resistance to antibiotics – Kurzweil AI – 7-May-15
Our goal was to find a precise, ordered schedule of antibiotics that doctors could rely on and know that in the end, resistance will be reversed, and an antibiotic will work

Most countries not protecting antibiotics, says WHO – BBC News – 29-Apr15
the globe is heading into a “post-antibiotic era” in which much of modern medicine becomes impossible.

Antibiotic switching ‘evades bacterial resistance’ – BBC News – 9-Apr-15

Antibiotic resistance: 80,000 ‘might die’ in future outbreak – BBC News – 6-Apr-15
Two in five might die.

Rapid blood test to ‘cut antibiotic use’ – BBC News – 19-Mar-15

Game-changing antibiotic find (teixobactin clears MRSA on mice) – BBC News – 7-Jan-15

Antibiotic resistance rise continues – BBC News – 10-Oct-14

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